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      Multidisciplinary approaches for targeting the secretase protein family as a therapeutic route for Alzheimer's disease

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          Notch Signaling: Cell Fate Control and Signal Integration in Development

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            Multi-target-directed ligands to combat neurodegenerative diseases.

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              Oxidative stress: A major pathogenesis and potential therapeutic target of antioxidative agents in Parkinson's disease and Alzheimer's disease.

              Oxidative stress reflects an imbalance between the overproduction and incorporation of free radicals and the dynamic ability of a biosystem to detoxify reactive intermediates. Free radicals produced by oxidative stress are one of the common features in several experimental models of diseases. Free radicals affect both the structure and function of neural cells, and contribute to a wide range of neurodegenerative diseases, including Parkinson's disease and Alzheimer's disease. Although the precise mechanisms that result in the degeneration of neurons and the relevant pathological changes remain unclear, the crucial role of oxidative stress in the pathogenesis of neurodegenerative diseases is associated with several proteins (such as α-synuclein, DJ-1, Amyloid β and tau protein) and some signaling pathways (such as extracellular regulated protein kinases, phosphoinositide 3-kinase/Protein Kinase B pathway and extracellular signal-regulated kinases 1/2) that are tightly associated with the neural damage. In this review, we present evidence, gathered over the last decade, concerning a variety of pathogenic proteins, their important signaling pathways and pathogenic mechanisms associated with oxidative stress in Parkinson's disease and Alzheimer's disease. Proper control and regulation of these proteins' functions and the related signaling pathways may be a promising therapeutic approach to the patients. We also emphasizes antioxidative options, including some new neuroprotective agents that eliminate excess reactive oxygen species efficiently and have a certain therapeutic effect; however, controversy surrounds some of them in terms of the dose and length of therapy. These agents require further investigation by clinical application in patients suffering Parkinson's disease and Alzheimer's disease.
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                Author and article information

                Journal
                Medicinal Research Reviews
                Med Res Rev
                Wiley
                01986325
                September 2019
                September 2019
                January 09 2019
                : 39
                : 5
                : 1730-1778
                Affiliations
                [1 ]Faculty of Medical Technology; Center of Data Mining and Biomedical Informatics, Mahidol University; Bangkok Thailand
                [2 ]Faculty of Medical Technology; Center for Research and Innovation, Mahidol University; Bangkok Thailand
                [3 ]Institute of Molecular Biosciences; Mahidol University; Nakhon Pathom Thailand
                [4 ]Centre National de la Recherche Scientifique; Paris France
                Article
                10.1002/med.21563
                30628099
                b2dc1be9-3d91-40bb-97ad-feeb392b62e1
                © 2019

                http://doi.wiley.com/10.1002/tdm_license_1.1

                http://onlinelibrary.wiley.com/termsAndConditions#vor

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