TLR9 agonist suppresses choroidal neovascularization by restricting endothelial cell motility via ERK/c-Jun pathway.

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Abstract

Choroidal neovascularization (CNV) is the feature of neovascular age-related macular degeneration (AMD). It has been demonstrated that inflammation plays a key role in the development of CNV. Here we aim to investigate how TLR9 agonist (CpG-ODN), one of the key regulators of inflammatory responses, suppresses CNV in vivo.

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Author and article information

Journal

Journal ID (iso-abbrev): Microvasc Res

Title: Microvascular research

Publisher: Elsevier BV

ISSN (Electronic): 1095-9319

ISSN (Print): 0026-2862

Publication date (Electronic): May 2022

Volume: 141

Affiliations

[1 ] College of Pharmacy, National & Local Joint Engineering Research Center of Targeted and Innovative Therapeutics, IATTI, Chongqing University of Arts and Sciences, Chongqing, China.

[2 ] Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai, China.

[3 ] Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, National Clinical Research Center for Eye Diseases, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai, China. Electronic address: jianeywu628@msn.com.

Article

Publisher Item ID: S0026-2862(22)00028-0

DOI: 10.1016/j.mvr.2022.104338

PubMed ID: 35150733

SO-VID: b3ed6321-b6ff-4747-b8b8-3d7530b8eb97

History

Keywords: CpG-ODN,Cell proliferation,Choroidal neovascularization,TLR9 agonist

Data availability:

Keywords: CpG-ODN, Cell proliferation, Choroidal neovascularization, TLR9 agonist

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