60
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Toward A Simulation-Based Tool for the Treatment of Vocal Fold Paralysis

      review-article

      Read this article at

      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Advances in high-performance computing are enabling a new generation of software tools that employ computational modeling for surgical planning. Surgical management of laryngeal paralysis is one area where such computational tools could have a significant impact. The current paper describes a comprehensive effort to develop a software tool for planning medialization laryngoplasty where a prosthetic implant is inserted into the larynx in order to medialize the paralyzed vocal fold (VF). While this is one of the most common procedures used to restore voice in patients with VF paralysis, it has a relatively high revision rate, and the tool being developed is expected to improve surgical outcomes. This software tool models the biomechanics of airflow-induced vibration in the human larynx and incorporates sophisticated approaches for modeling the turbulent laryngeal flow, the complex dynamics of the VFs, as well as the production of voiced sound. The current paper describes the key elements of the modeling approach, presents computational results that demonstrate the utility of the approach and also describes some of the limitations and challenges.

          Related collections

          Most cited references61

          • Record: found
          • Abstract: not found
          • Article: not found

          IMMERSED BOUNDARY METHODS

            Bookmark
            • Record: found
            • Abstract: not found
            • Article: not found

            DIRECT NUMERICAL SIMULATION: A Tool in Turbulence Research

              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              A VERSATILE SHARP INTERFACE IMMERSED BOUNDARY METHOD FOR INCOMPRESSIBLE FLOWS WITH COMPLEX BOUNDARIES.

              A sharp interface immersed boundary method for simulating incompressible viscous flow past three-dimensional immersed bodies is described. The method employs a multi-dimensional ghost-cell methodology to satisfy the boundary conditions on the immersed boundary and the method is designed to handle highly complex three-dimensional, stationary, moving and/or deforming bodies. The complex immersed surfaces are represented by grids consisting of unstructured triangular elements; while the flow is computed on non-uniform Cartesian grids. The paper describes the salient features of the methodology with special emphasis on the immersed boundary treatment for stationary and moving boundaries. Simulations of a number of canonical two- and three-dimensional flows are used to verify the accuracy and fidelity of the solver over a range of Reynolds numbers. Flow past suddenly accelerated bodies are used to validate the solver for moving boundary problems. Finally two cases inspired from biology with highly complex three-dimensional bodies are simulated in order to demonstrate the versatility of the method.
                Bookmark

                Author and article information

                Journal
                Front Physiol
                Front. Physio.
                Frontiers in Physiology
                Frontiers Research Foundation
                1664-042X
                12 March 2011
                02 May 2011
                2011
                : 2
                : 19
                Affiliations
                [1] 1simpleDepartment of Mechanical Engineering, Johns Hopkins University Baltimore, MD, USA
                [2] 2simpleInstitute for Computational Medicine, Johns Hopkins University Baltimore, MD, USA
                [3] 3simpleDivision of Otolaryngology, George Washington University Washington, DC, USA
                Author notes

                Edited by: Timothy W. Secomb, University of Arizona, USA

                Reviewed by: Ching-Long Lin, The University of Iowa, USA; Scott Thomson, Brigham Young University, USA

                *Correspondence: Rajat Mittal, 126 Latrobe, 3400 North Charles Street, Baltimore, MD 21218, USA. e-mail: mittal@ 123456jhu.edu

                This article was submitted to Frontiers in Computational Physiology and Medicine, a specialty of Frontiers in Physiology.

                Article
                10.3389/fphys.2011.00019
                3089877
                21556320
                b820fa25-6dd8-4f6a-a7a2-d46dd9cccda9
                Copyright © 2011 Mittal, Zheng, Bhardwaj, Seo, Xue and Bielamowicz.

                This is an open-access article subject to a non-exclusive license between the authors and Frontiers Media SA, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and other Frontiers conditions are complied with.

                History
                : 02 February 2011
                : 13 April 2011
                Page count
                Figures: 13, Tables: 1, Equations: 4, References: 77, Pages: 15, Words: 10497
                Categories
                Physiology
                Original Research

                Anatomy & Physiology
                surgical-planning,phonation,computational fluid dynamics,fluid-structure interaction,biomechanics

                Comments

                Comment on this article