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Gastrin releasing peptide reduces meal size in rats.


Animals, Rats, pharmacology, Peptides, Male, Gastrin-Releasing Peptide, Food Deprivation, drug effects, Eating, Dose-Response Relationship, Drug, Appetite Depressants

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      The satiety-eliciting effect of gastrin-releasing peptide (GRP), a putative mammalian counterpart of bombesin (BBS), was examined in mildly food-deprived rats. Intraperitoneal injections of GRP resulted in a significant decrease of 30-minute food intake at 2, 4, 8 and 16 micrograms/kg, while 1 microgram/kg had no reliable effect. Intraperitoneal GRP at 4 and 8 micrograms/kg did not suppress 30-minute water consumption by thirsty rats. When the dose-effect curves of GRP and BBS are compared on a molar scale, GRP is approximately 30% less potent than BBS in suppressing food intake. The two dose-effect curves are similar in shape and their regression lines have parallel slopes. These data lend further support to the hypothesis that GRP is a mammalian counterpart of BBS and strengthen the argument that they may function as endogenous satiety factors.

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