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The metabolic ER stress sensor IRE1α suppresses alternative activation of macrophages and impairs energy expenditure in obesity
Bo Shan ,
Xiaoxia Wang ,
Ying Wu ,
Chi Xu ,
Zhixiong Xia ,
Jianli Dai ,
Mengle Shao ,
Feng Zhao ,
Shengqi He ,
Liu Yang ,
Mingliang Zhang ,
Fajun Nan ,
Jia Li ,
Jianmiao Liu ,
Jianfeng Liu ,
Weiping Jia ,
Yifu Qiu ,
Baoliang Song ,
Jing-Dong J Han ,
Liangyou Rui ,
Sheng-Zhong Duan ,
Yong Liu
March 27 2017
March 27 2017
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Abstract
‘Crown-like’ structures composed of apoptotic adipocytes surrounded by adipose tissue macrophages (ATMs) are a characteristic of obesity. Liu and colleagues show that engulfment of apoptotic adipocytes triggers an ER stress response in ATMs and drives the proinflammatory response that underlies obesity.