Editorial
Critical care is a rapidly growing specialty. As a mark of its increasing maturity
and health, its practitioners are increasingly challenging long-held dogma and revising
practice guidelines. Critical care certainly punches well beyond its weight, accounting
for a disproportionately large number of clinical trials reported in the highest impact
factor journals. An impressive level of altruistic collaboration has often driven
such studies, even on shoestring budgets. Outcomes have improved, in large part due
to improvements in general care, early recognition of deterioration, and avoidance
of iatrogenic harm.
Notwithstanding these achievements, few novel drugs or other interventions that have
impacted positively on patient outcomes have come to the fore over the last 20 to
30 years. This disconnect highlights the crucial disparity between the clinical and
biological phenotypes of critical illness. Treatment strategies based on clinical
syndromic presentations, e.g. for sepsis, acute respiratory distress syndrome, and
acute kidney injury, have repeatedly fallen short of their initial promise. The heterogeneity
of the population with respect to age, gender, underlying comorbidity, trajectory
and severity of illness, time to presentation, infecting organism, and the type and
number of affected organs adds further complexity to trialing within an already challenging
patient cohort. Some interventions, albeit based on a seemingly sound rationale, have
even been associated with patient harm.
It is starkly obvious that improving our still limited grasp of the underlying pathophysiology
is key to making major advances in patient management. Yet, basic/translational research
has been traditionally relegated to a minor role and is generally undervalued by the
clinical community. This is reflected by a relatively low profile at (inter)national
congresses, fewer funding opportunities, and comparatively few basic scientists specifically
focusing on critical care conditions and pathologies. Even the specialist journals
generally eschew basic/translational papers, particularly those involving animal or
laboratory models. However, in their defence, the quality of such work is somewhat
variable, thus creating a perfect Catch 22 situation of struggling to attract the
funding and quality researchers needed to improve the overall calibre of the research
output.
With this in mind, Intensive Care Medicine, the official journal of the European Society
of Intensive Care Medicine (ESICM), has taken the bold step of splitting into two
separate but closely linked sister journals. Intensive Care Medicine will continue
as a solely clinical journal, reporting clinical trials, process of care, ethical
issues, health economics, and so forth. Intensive Care Medicine Experimental (ICMx)
will focus on experimental research, stretching from cell and in silico models, through
in vivo and ex vivo laboratory studies, to human volunteer and patient studies, where
the emphasis is on biology rather than on clinical outcomes.
The risk is that clinicians will choose to ignore this stand-alone offering. Yet,
we hope that offering a dedicated platform for such research will promote its importance,
elevate standards, improve transferability of findings from bench to bedside (and
back), and stimulate clinicians, basic scientists and, particularly, the next generations
of researchers to actively participate. In conjunction, other initiatives will be
taken by ESICM to elevate basic and translational research and encourage engagement.
Intensive Care Medicine Experimental (icm-experimental.com) will be an online-only
electronic journal that, by being open access, will guarantee rapid and widespread
dissemination of data, but with the assurance of decent, high-quality peer review
[1]. Being part of the SpringerOpen stable, it provides quality processing of manuscripts
and numerous portals to publicize the papers (including social media). This will be
complemented by the ESICM website that will promote the journal on its front page.
A strong endorsement has come from the ready acceptance by a cadre of 40 top-flight
researchers to take on active roles as Senior Editors and Editors, with commitments
to lend their significant expertise to the peer review process, to submit their research,
and to offer enthusiastic promotion in support of this fledgling journal. These researchers
are a healthy mix of basic scientists and clinician scientists whose research activities
have led them to embrace experimental research in distinct areas of critical care
(inflammation, immunity, respiratory, metabolic, neurological, endocrine, trauma,
and so forth). ICMx will thus, uniquely, be driven by the critical care community
with a sole focus on basic to translational research.
As with any new offering, the first few years will be challenging. We are, however,
quietly confident that it will succeed and sincerely hope the scientific community
will join in this exciting journey.