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Novel modulator for endothelial adhesion molecules: adipocyte-derived plasma protein adiponectin.
N Ouchi
1 ,
S Kihara ,
Y Arita ,
K Maeda ,
H Kuriyama ,
Y Okamoto ,
K Hotta ,
M Nishida ,
M Takahashi ,
T Nakamura ,
S Yamashita ,
T Funahashi ,
Y Matsuzawa
December 22 1999
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Abstract
Among the many adipocyte-derived endocrine factors, we recently found an adipocyte-specific secretory protein, adiponectin, which was decreased in obesity. Although obesity is associated with increased cardiovascular mortality and morbidity, the molecular basis for the link between obesity and vascular disease has not been fully clarified. The present study investigated whether adiponectin could modulate endothelial function and relate to coronary disease.