2
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Sleeping pattern and activities of daily living modulate protein expression in AMD

      research-article

      Read this article at

      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Degeneration of macular photoreceptors is a prominent characteristic of age-related macular degeneration (AMD) which leads to devastating and irreversible vision loss in the elderly population. In this exploratory study, the contribution of environmental factors on the progression of AMD pathology by probing the expression of candidate proteins was analyzed. Four hundred and sixty four participants were recruited in the study comprising of AMD (n = 277) and controls (n = 187). Genetics related data was analyzed to demonstrate the activities of daily living (ADL) by using regression analysis and statistical modeling, including contrast estimate, multinomial regression analysis in AMD progression. Regression analysis revealed contribution of smoking, alcohol, and sleeping hours on AMD by altered expression of IER-3, HTRA1, B3GALTL, LIPC and TIMP3 as compared to normal levels. Contrast estimate supports the gender polarization phenomenon in AMD by significant decreased expression of SLC16A8 and LIPC in control population which was found to be unaltered in AMD patients. The smoking, food habits and duration of night sleeping hours also contributed in AMD progression as evident from multinomial regression analysis. Predicted model (prediction estimate = 86.7%) also indicated the crucial role of night sleeping hours along with the decreased expression of TIMP-3, IER3 and SLC16A8. Results revealed an unambiguous role of environmental factors in AMD progression mediated by various regulatory proteins which might result in intermittent AMD phenotypes and possibly influence the outcome of anti-VEGF treatment.

          Related collections

          Most cited references49

          • Record: found
          • Abstract: found
          • Article: found

          Seven New Loci Associated with Age-Related Macular Degeneration

          Age-related macular degeneration (AMD) is a common cause of blindness in older individuals. To accelerate understanding of AMD biology and help design new therapies, we executed a collaborative genomewide association study, examining >17,100 advanced AMD cases and >60,000 controls of European and Asian ancestry. We identified 19 genomic loci associated with AMD with p<5×10−8 and enriched for genes involved in regulation of complement activity, lipid metabolism, extracellular matrix remodeling and angiogenesis. Our results include 7 loci reaching p<5×10−8 for the first time, near the genes COL8A1/FILIP1L, IER3/DDR1, SLC16A8, TGFBR1, RAD51B, ADAMTS9/MIR548A2, and B3GALTL. A genetic risk score combining SNPs from all loci displayed similar good ability to distinguish cases and controls in all samples examined. Our findings provide new directions for biological, genetic and therapeutic studies of AMD.
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Hypomethylation of the IL17RC promoter associates with age-related macular degeneration.

            Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in the elderly population worldwide. Although recent studies have demonstrated strong genetic associations between AMD and SNPs in a number of genes, other modes of regulation are also likely to play a role in the etiology of this disease. We identified a significantly decreased level of methylation on the IL17RC promoter in AMD patients. Furthermore, we showed that hypomethylation of the IL17RC promoter in AMD patients led to an elevated expression of its protein and messenger RNA in peripheral blood as well as in the affected retina and choroid, suggesting that the DNA methylation pattern and expression of IL17RC may potentially serve as a biomarker for the diagnosis of AMD and likely plays a role in disease pathogenesis. Copyright © 2012 The Authors. Published by Elsevier Inc. All rights reserved.
              Bookmark
              • Record: found
              • Abstract: found
              • Article: found
              Is Open Access

              Smoking and Age-Related Macular Degeneration: Review and Update

              Age-related macular degeneration (AMD) is one of the main socioeconomical health issues worldwide. AMD has a multifactorial etiology with a variety of risk factors. Smoking is the most important modifiable risk factor for AMD development and progression. The present review summarizes the epidemiological studies evaluating the association between smoking and AMD, the mechanisms through which smoking induces damage to the chorioretinal tissues, and the relevance of advising patients to quit smoking for their visual health.
                Bookmark

                Author and article information

                Contributors
                Role: ConceptualizationRole: Formal analysisRole: InvestigationRole: MethodologyRole: SoftwareRole: Writing – original draft
                Role: InvestigationRole: MethodologyRole: Writing – review & editing
                Role: Formal analysisRole: SupervisionRole: Writing – review & editing
                Role: ConceptualizationRole: Funding acquisitionRole: Project administrationRole: Writing – review & editing
                Role: Editor
                Journal
                PLoS One
                PLoS One
                plos
                plosone
                PLoS ONE
                Public Library of Science (San Francisco, CA USA )
                1932-6203
                1 June 2021
                2021
                : 16
                : 6
                : e0248523
                Affiliations
                [1 ] Neuroscience Research Lab, Department of Neurology, Post Graduate Institute of Medical Education and Research, Chandigarh, India
                [2 ] Advanced Pediatrics Centre, Department of Pediatrics, Post Graduate Institute of Medical Education and Research, Chandigarh, India
                [3 ] Department of Ophthalmology, Post Graduate Institute of Medical Education and Research, Chandigarh, India
                [4 ] Department of Statistics, Panjab University, Chandigarh, India
                University of Florida, UNITED STATES
                Author notes

                Competing Interests: The authors have declared that no competing interests exist.

                Author information
                https://orcid.org/0000-0001-9003-3532
                Article
                PONE-D-20-29337
                10.1371/journal.pone.0248523
                8168906
                34061866
                beb996dc-eeb3-4d16-93e4-b85c9be52ebf
                © 2021 Sharma et al

                This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

                History
                : 17 September 2020
                : 26 February 2021
                Page count
                Figures: 1, Tables: 7, Pages: 17
                Funding
                Funded by: Department of Biotechnology, New Delhi, India
                Award ID: No. BT/PR17550/MED/30/1755/2016
                Award Recipient :
                Funded by: CSIR-UGC, New Delhi
                Award Recipient :
                Funded by: Department of Science and Technology (DST), New Delhi, India
                Award Recipient :
                Funded by: Indian Council of Medical Research (ICMR), New Delhi, India
                Award Recipient :
                This study was funded by the Department of Biotechnology, New Delhi, India to AA (No. BT/PR17550/MED/30/1755/2016). We also acknowledge CSIR-UGC, New Delhi for providing fellowship during PhD to KS, Department of Science and Technology (DST), New Delhi, India and Indian Council of Medical Research (ICMR), New Delhi, India to provide the travel funds to KS. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
                Categories
                Research Article
                Biology and Life Sciences
                Nutrition
                Diet
                Alcohol Consumption
                Medicine and Health Sciences
                Nutrition
                Diet
                Alcohol Consumption
                Biology and Life Sciences
                Psychology
                Behavior
                Habits
                Eating Habits
                Social Sciences
                Psychology
                Behavior
                Habits
                Eating Habits
                Biology and Life Sciences
                Molecular Biology
                Molecular Biology Techniques
                Molecular Biology Assays and Analysis Techniques
                Gene Expression and Vector Techniques
                Protein Expression
                Research and Analysis Methods
                Molecular Biology Techniques
                Molecular Biology Assays and Analysis Techniques
                Gene Expression and Vector Techniques
                Protein Expression
                Medicine and Health Sciences
                Health Care
                Quality of Life
                Activities of Daily Living
                Biology and Life Sciences
                Genetics
                Genetics of Disease
                Medicine and Health Sciences
                Geriatrics
                Geriatric Ophthalmology
                Macular Degeneration
                Medicine and Health Sciences
                Ophthalmology
                Geriatric Ophthalmology
                Macular Degeneration
                Medicine and Health Sciences
                Medical Conditions
                Eye Diseases
                Retinal Disorders
                Macular Disorders
                Macular Degeneration
                Medicine and Health Sciences
                Ophthalmology
                Eye Diseases
                Retinal Disorders
                Macular Disorders
                Macular Degeneration
                Medicine and Health Sciences
                Medical Conditions
                Eye Diseases
                Retinal Disorders
                Retinal Degeneration
                Macular Degeneration
                Medicine and Health Sciences
                Ophthalmology
                Eye Diseases
                Retinal Disorders
                Retinal Degeneration
                Macular Degeneration
                Research and Analysis Methods
                Mathematical and Statistical Techniques
                Statistical Methods
                Regression Analysis
                Physical Sciences
                Mathematics
                Statistics
                Statistical Methods
                Regression Analysis
                Medicine and Health Sciences
                Surgical and Invasive Medical Procedures
                Ophthalmic Procedures
                Cataract Surgery
                Custom metadata
                All relevant data are in the paper and its Supporting Information files.

                Uncategorized
                Uncategorized

                Comments

                Comment on this article