Kennedy Aldrich: Role: Formal analysisRole: InvestigationRole: Writing – original draftRole: Writing
– review & editing
Deborah Velez-Irizarry: Role: Data curationRole: Formal analysisRole: MethodologyRole: Writing – review &
editing
Clara Fenger: Role: ConceptualizationRole: InvestigationRole: Writing – review & editing
Melissa Schott: Role: Formal analysisRole: MethodologyRole: Writing – review & editing
Stephanie J. Valberg:
ORCID: https://orcid.org/0000-0001-5978-7010
Role: ConceptualizationRole: InvestigationRole: Project administrationRole: ResourcesRole:
Writing – review & editing
Agustín Guerrero-Hernandez: Role: Editor
Journal ID (nlm-ta): PLoS One
Journal ID (iso-abbrev): PLoS One
Journal ID (publisher-id): plos
Journal ID (pmc): plosone
Title:
PLoS ONE
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Electronic):
1932-6203
Publication date
(Electronic):
10
February
2021
Publication date Collection: 2021
Volume: 16
Issue: 2
Electronic Location Identifier: e0244556
Affiliations
[1
]
Mary Anne McPhail Equine Performance Center, Large Animal Clinical Sciences, College
of Veterinary Medicine, Michigan State University, East Lansing, MI, United States
of America
[2
]
Equine Integrated Medicine, PLC, Lexington, KY, United States of America
Author notes
Competing Interests: One of the authors (CF) is a practicing veterinarian and owner of the business Equine
Integrated Medicine PLC. There are no other relevant declarations relating to employment,
consultancy, patents, products in development, or marketed products. This does not
alter our adherence to PLOS ONE policies on sharing data and materials.
Author information
Article
Publisher ID:
PONE-D-20-29481
DOI: 10.1371/journal.pone.0244556
PMC ID: 7875397
PubMed ID: 33566847
SO-VID: c0c23e7d-5560-4ea0-b271-7f76bb5357cd
Copyright © © 2021 Aldrich et al
License:
This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided
the original author and source are credited.
Funded by: funder-id http://dx.doi.org/10.13039/100001655, Grayson-Jockey Club Research Foundation;
Award Recipient
:
ORCID: https://orcid.org/0000-0001-5978-7010
Stephanie J. Valberg
Funded by: Mary Anne McPhail Endowment
Award Recipient
:
ORCID: https://orcid.org/0000-0001-5978-7010
Stephanie J. Valberg
Funded by: funder-id http://dx.doi.org/10.13039/100000002, National Institutes of Health;
Award ID: T32 OD011167
Award Recipient
:
Kennedy Aldrich
Research was supported by the Grayson Jockey Club Research Foundation (SJV), the Mary
Anne McPhail Endowment at Michigan State University (SJV) and in part by NIH Grant
T32 OD011167 to Michigan State University (KJA). The Grayson Jockey Club Research
Foundation provided funds to perform the research study and partial salary for one
author (DVI). CF is the owner of Equine Integrated Medicine PLC. and identified horses
in her practice that were healthy controls or susceptible to RER and facilitated biopsy
samples that were obtained by another author (SJV). CF did not receive any financial
remuneration for participating in the study. The specific role of these authors is
articulated in the 'author contributions' section. The funders had no role in study
design, data collection and analysis, decision to publish, or preparation of the manuscript.
Subject:
Research Article
Subject:
Biology and Life Sciences
Subject:
Organisms
Subject:
Eukaryota
Subject:
Animals
Subject:
Vertebrates
Subject:
Amniotes
Subject:
Mammals
Subject:
Equines
Subject:
Horses
Subject:
Biology and Life Sciences
Subject:
Zoology
Subject:
Animals
Subject:
Vertebrates
Subject:
Amniotes
Subject:
Mammals
Subject:
Equines
Subject:
Horses
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Bioenergetics
Subject:
Energy-Producing Organelles
Subject:
Mitochondria
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cellular Structures and Organelles
Subject:
Energy-Producing Organelles
Subject:
Mitochondria
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cellular Structures and Organelles
Subject:
Cell Membranes
Subject:
Membrane Proteins
Subject:
Biology and Life Sciences
Subject:
Computational Biology
Subject:
Genome Analysis
Subject:
Gene Ontologies
Subject:
Biology and Life Sciences
Subject:
Genetics
Subject:
Genomics
Subject:
Genome Analysis
Subject:
Gene Ontologies
Subject:
Biology and Life Sciences
Subject:
Genetics
Subject:
Gene Expression
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Proteins
Subject:
Muscle Proteins
Subject:
Biology and Life Sciences
Subject:
Molecular Biology
Subject:
Molecular Biology Techniques
Subject:
Molecular Biology Assays and Analysis Techniques
Subject:
Gene Expression and Vector Techniques
Subject:
Protein Expression
Subject:
Research and Analysis Methods
Subject:
Molecular Biology Techniques
Subject:
Molecular Biology Assays and Analysis Techniques
Subject:
Gene Expression and Vector Techniques
Subject:
Protein Expression
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cellular Structures and Organelles
Subject:
Endoplasmic Reticulum
Subject:
Sarcoplasmic Reticula
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cell Processes
Subject:
Secretory Pathway
Subject:
Endoplasmic Reticulum
Subject:
Sarcoplasmic Reticula