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      Mitochondria targeting by environmental stressors: implications for redox cellular signaling

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      Toxicology

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          Abstract

          Mitochondria are cellular powerhouses as well as metabolic and signaling hubs, regulating diverse cellular functions from basic physiology to phenotypic fate determination. It is widely accepted that reactive oxygen species (ROS) generated in mitochondria participate in the regulation of cellular signaling and that there are mitochondria which operate at a high ROS baseline. However, how mitochondria adapt to persistently high ROS states as well as to environmental stressors that disturb the redox balance is not completely understood. Here we will review some of the current concepts regarding how mitochondria resist oxidative damage, how they are replaced when oxidative damage is excessive to an extent that compromises function, and what is the effect of some environmental toxicants (i.e. heavy metals) on the regulation of mitochondrial ROS (mtROS) production which are linked to their toxic effects on cells and tissues.

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          Author and article information

          Journal
          0361055
          7770
          Toxicology
          Toxicology
          Toxicology
          0300-483X
          1879-3185
          3 May 2018
          24 July 2017
          01 November 2017
          08 May 2018
          : 391
          : 84-89
          Affiliations
          Departments of Medicine and Pathology
          Author notes
          [§ ]Correspondence to: Marcelo G. Bonini, Ph.D., Departments of Medicine, Pathology and Pharmacology, University of Illinois at Chicago, UIC, 909 S. Wolcott Ave, COMRB 1131, Chicago, IL, 60612, Phone – (312) 355-5948 mbonini@ 123456uic.edu
          Article
          PMC5939563 PMC5939563 5939563 nihpa964527
          10.1016/j.tox.2017.07.013
          5939563
          28750850
          Categories
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