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Scalarane-based sesterterpenoid RCE-protease inhibitors isolated from the Indonesian marine sponge Carteriospongia foliascens.

Author(s): Larry Feldberg, Joseph D. Williams, Robert Mallon, Akbar Tahir, Eileen Frommer, Raymond Andersen, Rob van Lier, Irwin Hollander

Publication date: 2009-05-31

Journal: Journal of Natural Products

Keywords: Animals, Endopeptidases, drug effects, Humans, Indonesia, Marine Biology, Molecular Structure, Porifera, chemistry, Protease Inhibitors, isolation & purification, pharmacology, Sesterterpenes

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Abstract

Two new 20,24-bishomo-25-norscalaranes, compounds 1 and 2, and two new and two known 20,24-bishomoscalaranes, compounds 3-6, have been isolated from the Indonesian marine sponge Carteriospongia foliascens. The structures of 1-6 were determined by spectroscopic analysis. Compounds 1 and 3-6 inhibit RCE-protease activity.

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PubMed ID:: 19485329

DOI:: 10.1021/np900042r

ScienceOpen disciplines: Chemistry

Keywords: Animals,Endopeptidases,drug effects,Humans,Indonesia,Marine Biology,Molecular Structure,Porifera,chemistry,Protease Inhibitors,isolation & purification,pharmacology,Sesterterpenes

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ScienceOpen disciplines: Chemistry

Scalarane-based sesterterpenoid RCE-protease inhibitors isolated from the Indonesian marine sponge Carteriospongia foliascens.

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Porifera

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