Contributors
Ditte Olsen Lützhøft: Role: Data curationRole: Formal analysisRole: VisualizationRole: Writing – original
draftRole: Writing – review & editing
Cecilie Bækgård: Role: Data curationRole: Writing – original draft
Elizabeth Wimborne:
ORCID: https://orcid.org/0000-0001-8471-4489
Role: Data curationRole: Formal analysisRole: Visualization
Ellen Marie Straarup: Role: Data curationRole: SupervisionRole: Writing – review & editing
Karen-Margrethe Pedersen: Role: SupervisionRole: Writing – review & editing
Jonathan R. Swann: Role: Data curationRole: Formal analysisRole: VisualizationRole: Writing – review
& editing
Henrik Duelund Pedersen: Role: ConceptualizationRole: InvestigationRole: Project administrationRole: Writing
– review & editing
Kim Kristensen: Role: Formal analysisRole: Writing – review & editing
Line Morgills: Role: InvestigationRole: Writing – review & editing
Dennis Sandris Nielsen: Role: SupervisionRole: Writing – review & editing
Axel Kornerup Hansen: Role: SupervisionRole: Writing – review & editing
Marianne Kronborg Bracken: Role: ConceptualizationRole: Data curationRole: InvestigationRole: Project administrationRole:
Writing – review & editing
Susanna Cirera: Role: Data curationRole: Formal analysisRole: SupervisionRole: Writing – original
draftRole: Writing – review & editing
Berit Østergaard Christoffersen:
ORCID: https://orcid.org/0000-0002-6867-2757
Role: ConceptualizationRole: Data curationRole: Funding acquisitionRole: SupervisionRole:
Writing – original draftRole: Writing – review & editing
Utpal Sen: Role: Editor
Journal
Journal ID (nlm-ta): PLoS One
Journal ID (iso-abbrev): PLoS One
Journal ID (publisher-id): plos
Title:
PLOS ONE
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Electronic):
1932-6203
Publication date
(Electronic):
1
March
2024
Publication date Collection: 2024
Volume: 19
Issue: 3
Electronic Location Identifier: e0298602
Affiliations
[1
]
Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences,
University of Copenhagen, Frederiksberg C, Denmark
[2
]
School of Human Development and Health, Faculty of Medicine, University of Southampton,
Southampton, United Kingdom
[3
]
Novo Nordisk A/S, Maaloev, Denmark
[4
]
Ellegaard Göttingen Minipigs A/S, Dalmose, Denmark
[5
]
Department of Food Science, Faculty of Science, University of Copenhagen, Frederiksberg
C, Denmark
[6
]
Scantox A/S, Lille Skensved, Denmark
University of Louisville, UNITED STATES
Author notes
Competing Interests: All authors have have read the journal’s policy and the authors of this manuscript
have the following competing interests: BØC, KMP, EMS, HDP and KK are full time employees
at Novo Nordisk A/S and minor share-holders. LM and MKB were employed at Scantox A/S
at the time of the study. HDP was employed at Ellegaard Göttingen Minipigs A/S at
the time of the study. AHK declares potential conflict of interest as stated on
https://ivh.ku.dk/english/employees/?pure=en/persons/107126. DOL declares potential conflict of interest as stated on
https://ivh.ku.dk/ansatte/?pure=da/persons/392109. Otherwise, the authors have no conflicts of interest to declare
[¤]
Current address: Novo Nordisk A/S, Maaloev, Denmark
Author information
Article
Publisher ID:
PONE-D-23-20796
DOI: 10.1371/journal.pone.0298602
PMC ID: 10906878
PubMed ID: 38427692
SO-VID: c2075247-2586-4430-962d-dfd10e32286c
Copyright © © 2024 Lützhøft et al
License:
This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided
the original author and source are credited.
History
Date
received
: 6
July
2023
Date
accepted
: 26
January
2024
Page count
Figures: 6,
Tables: 2,
Pages: 27
Funding
Funded by:
https://www.lifepharm.ku.dk/research/phd-projects/
Award ID: 00000000
Award Recipient
:
Ditte Olsen Lützhøft
Funded by:
Novo Nordisk A/S, Denmark
Funded by:
Scantox A/S
Funded by:
funder-id http://dx.doi.org/10.13039/100019147, Universitätsmedizin Göttingen;
This study was co-financed by Ellegaard Göttingen Minipigs A/S, Scantox A/S and Novo
Nordisk A/S, and employees at these three companies were part of he study design,
data collection and analysis, decision to publish and preparation of the manuscript.
DOL was financed by the LIFEPHARM center,
www.lifepharm.ku.dk.
Categories
Subject:
Research Article
Subject:
Biology and Life Sciences
Subject:
Nutrition
Subject:
Diet
Subject:
Medicine and Health Sciences
Subject:
Nutrition
Subject:
Diet
Subject:
Biology and Life Sciences
Subject:
Physiology
Subject:
Physiological Parameters
Subject:
Body Weight
Subject:
Obesity
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Biological Tissue
Subject:
Connective Tissue
Subject:
Adipose Tissue
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Biological Tissue
Subject:
Connective Tissue
Subject:
Adipose Tissue
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Metabolism
Subject:
Carbohydrate Metabolism
Subject:
Glucose Metabolism
Subject:
Biology and Life Sciences
Subject:
Organisms
Subject:
Bacteria
Subject:
Gut Bacteria
Subject:
Medicine and Health Sciences
Subject:
Endocrinology
Subject:
Diabetic Endocrinology
Subject:
Insulin
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Hormones
Subject:
Insulin
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Metabolism
Subject:
Metabolites
Subject:
Medicine and Health Sciences
Subject:
Endocrinology
Subject:
Endocrine Physiology
Subject:
Insulin Resistance
Subject:
Biology and Life Sciences
Subject:
Physiology
Subject:
Endocrine Physiology
Subject:
Insulin Resistance
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