For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
2
views
56
references
 Top references
cited by
0
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
0 collections
    0
    shares
      123
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Effects of extreme meteorological factors and high air pollutant concentrations on the incidence of hand, foot and mouth disease in Jining, China

      research-article

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Background

          The evidence on the effects of extreme meteorological conditions and high air pollution levels on incidence of hand, foot and mouth disease (HFMD) is limited. Moreover, results of the available studies are inconsistent. Further investigations are imperative to elucidate the specific issue.

          Methods

          Data on the daily cases of HFMD, meteorological factors and air pollution were obtained from 2017 to 2022 in Jining City. We employed distributed lag nonlinear model (DLNM) incorporated with Poisson regression to explore the impacts of extreme meteorological conditions and air pollution on HFMD incidence.

          Results

          We found that there were nonlinear relationships between temperature, wind speed, PM 2.5, SO 2, O 3 and HFMD. The cumulative risk of extreme high temperature was higher at the 95th percentile ( P 95 th) than at the 90th percentile( P 90 th), and the RR values for both reached their maximum at 10-day lag ( P 95 th RR = 1.880 (1.261–2.804), P 90 th RR = 1.787 (1.244–2.569)), the hazardous effect of extreme low temperatures on HFMD is faster than that of extreme high temperatures. The cumulative effect of extreme low wind speeds reached its maximum at 14-day lag ( P 95 th RR = 1.702 (1.389-2.085), P 90 th RR = 1.498(1.283–1.750)). The cumulative effect of PM 2.5 concentration at the P 90th was largest at 14-day lag ( RR = 1.637 (1.069–2.506)), and the cumulative effect at the P 95 th was largest at 10-day lag ( RR = 1.569 (1.021–2.411)). High SO 2 concentration at the P 95 th at 14-day lag was associated with higher risk for HFMD ( RR: 1.425 (1.001–2.030)).

          Conclusion

          Our findings suggest that high temperature, low wind speed, and high concentrations of PM2.5 and SO2 are associated with an increased risk of HFMD. This study not only adds insights to the understanding of the impact of extreme meteorological conditions and high levels of air pollutants on HFMD incidence but also holds practical significance for the development and enhancement of an early warning system for HFMD.

          Related collections

          Most cited references56

          • Record: found
          • Abstract: found
          • Article: not found

          Distributed Lag Linear and Non-Linear Models in R: The Package dlnm.

          Antonio Gasparrini (2011)
          Distributed lag non-linear models (DLNMs) represent a modeling framework to flexibly describe associations showing potentially non-linear and delayed effects in time series data. This methodology rests on the definition of a crossbasis, a bi-dimensional functional space expressed by the combination of two sets of basis functions, which specify the relationships in the dimensions of predictor and lags, respectively. This framework is implemented in the R package dlnm, which provides functions to perform the broad range of models within the DLNM family and then to help interpret the results, with an emphasis on graphical representation. This paper offers an overview of the capabilities of the package, describing the conceptual and practical steps to specify and interpret DLNMs with an example of application to real data.
          Article 0 comments Cited 304 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Clinical features, diagnosis, and management of enterovirus 71.

            Mong How Ooi, See Chang Wong, Penny Lewthwaite … (2010)
            Although poliomyelitis has been mostly eradicated worldwide, large outbreaks of the related enterovirus 71 have been seen in Asia-Pacific countries in the past 10 years. This virus mostly affects children, manifesting as hand, foot, and mouth disease, aseptic meningitis, poliomyelitis-like acute flaccid paralysis, brainstem encephalitis, and other severe systemic disorders, including especially pulmonary oedema and cardiorespiratory collapse. Clinical predictors of severe disease include high temperature and lethargy, and lumbar puncture might reveal pleocytosis. Many diagnostic tests are available, but PCR of throat swabs and vesicle fluid, if available, is among the most efficient. Features of inflammation, particularly in the anterior horns of the spinal cord, the dorsal pons, and the medulla can be clearly seen on MRI. No established antiviral treatment is available. Intravenous immunoglobulin seems to be beneficial in severe disease, perhaps through non-specific anti-inflammatory mechanisms, but has not been tested in any formal trials. Milrinone might be helpful in patients with cardiac dysfunction. Copyright © 2010 Elsevier Ltd. All rights reserved.
            Article 0 comments Cited 301 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Neurologic complications in children with enterovirus 71 infection.

              C. C-C Huang, C. C. Liu, Y C Chang … (1999)
              Enterovirus 71 infection causes hand-foot-and-mouth disease in young children, which is characterized by several days of fever and vomiting, ulcerative lesions in the oral mucosa, and vesicles on the backs of the hands and feet. The initial illness resolves but is sometimes followed by aseptic meningitis, encephalomyelitis, or even acute flaccid paralysis similar to paralytic poliomyelitis. We describe the neurologic complications associated with the enterovirus 71 epidemic that occurred in Taiwan in 1998. At three major hospitals we identified 41 children with culture-confirmed enterovirus 71 infection and acute neurologic manifestations. Magnetic resonance imaging (MRI) was performed in 4 patients with acute flaccid paralysis and 24 with rhombencephalitis. The mean age of the patients was 2.5 years (range, 3 months to 8.2 years). Twenty-eight patients had hand-foot-and-mouth disease (68 percent), and 6 had herpangina (15 percent). The other seven patients had no skin or mucosal lesions. Three neurologic syndromes were identified: aseptic meningitis (in 3 patients); brain-stem encephalitis, or rhombencephalitis (in 37); and acute flaccid paralysis (in 4), which followed rhombencephalitis in 3 patients. In 20 patients with rhombencephalitis, the syndrome was characterized by myoclonic jerks and tremor, ataxia, or both (grade I disease). Ten patients had myoclonus and cranial-nerve involvement (grade II disease). In seven patients the brain-stem infection produced transient myoclonus followed by the rapid onset of respiratory distress, cyanosis, poor peripheral perfusion, shock, coma, loss of the doll's eye reflex, and apnea (grade III disease); five of these patients died within 12 hours after admission. In 17 of the 24 patients with rhombencephalitis who underwent MRI, T2-weighted scans showed high-intensity lesions in the brain stem, most commonly in the pontine tegmentum. At follow-up, two of the patients with acute flaccid paralysis had residual limb weakness, and five of the patients with rhombencephalitis had persistent neurologic deficits, including myoclonus (in one child), cranial-nerve deficits (in two), and ventilator-dependent apnea (in two). In the 1998 enterovirus 71 epidemic in Taiwan, the chief neurologic complication was rhombencephalitis, which had a fatality rate of 14 percent. The most common initial symptoms were myoclonic jerks, and MRI usually showed evidence of brainstem involvement.
              Article 0 comments Cited 180 times – based on 0 reviews     Review now
                Bookmark
                All references

                Author and article information

                Contributors
                Wenjun Wang
                Juxiang Yuan
                Journal
                Journal ID (nlm-ta): PeerJ
                Journal ID (iso-abbrev): PeerJ
                Journal ID (publisher-id): PeerJ
                Title: PeerJ
                Publisher: PeerJ Inc. (San Diego, USA )
                ISSN (Electronic): 2167-8359
                Publication date (Electronic): 15 May 2024
                Publication date Collection: 2024
                Volume: 12
                Electronic Location Identifier: e17163
                Affiliations
                [1 ]School of Public Health, North China University of Science and Technology , Tangshan, Hebei Province, China
                [2 ]State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences , Beijing, China
                [3 ]Business Management Department, Jining Center For Disease Control And Prevention , Jining, Shandong, China
                [4 ]Infectious Disease Prevention and Control Department, Jining Center For Disease Control And Prevention , Jining, Shandong, China
                [5 ]Department of Radiology, The First Affiliated Hospital of Chongqing Medical University , Chongqing, China
                [6 ]Weifang Nursing Vocational College , Weifang, Shandong, China
                Article
                Publisher ID: 17163
                DOI: 10.7717/peerj.17163
                PMC ID: 11102053
                PubMed ID: 38766480
                SO-VID: c4366d5b-d9e6-4156-a775-fec07197c2ff
                Copyright © © 2024 Cao et al.
                License:

                This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited.

                History
                Date received : 9 November 2023
                Date accepted : 6 March 2024
                Funding
                Funded by: National Key Projects of Research and Development of China
                Award ID: 2016YFC0900605
                This work was supported by the National Key Projects of Research and Development of China (No. 2016YFC0900605). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
                Categories
                Subject: Epidemiology
                Subject: Pediatrics
                Subject: Public Health
                Subject: Environmental Health

                Keywords: extreme meteorological factors,high pollutant concentration,influencing factors,hand, foot and mouth disease
                Data availability:
                Keywords: extreme meteorological factors, high pollutant concentration, influencing factors, hand, foot and mouth disease

                Comments

                Comment on this article

                scite_

                Similar content123

                See all similar

                Most referenced authors664

                See all reference authors