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      A review of performance of near-infrared fluorescence imaging devices used in clinical studies

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      The British Journal of Radiology

      British Institute of Radiology

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          Abstract

          Near-infrared fluorescence (NIRF) molecular imaging holds great promise as a new "point-of-care" medical imaging modality that can potentially provide the sensitivity of nuclear medicine techniques, but without the radioactivity that can otherwise place limitations of usage. Recently, NIRF imaging devices of a variety of designs have emerged in the market and in investigational clinical studies using indocyanine green (ICG) as a non-targeting NIRF contrast agent to demark the blood and lymphatic vasculatures both non-invasively and intraoperatively. Approved in the USA since 1956 for intravenous administration, ICG has been more recently used off label in intradermal or subcutaneous administrations for fluorescence imaging of the lymphatic vasculature and lymph nodes. Herein, we summarize the devices of a variety of designs, summarize their performance in lymphatic imaging in a tabular format and comment on necessary efforts to develop standards for device performance to compare and use these emerging devices in future, NIRF molecular imaging studies.

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          Most cited references 125

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          Shedding light onto live molecular targets.

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            The clinical use of indocyanine green as a near-infrared fluorescent contrast agent for image-guided oncologic surgery.

            Optical imaging using near-infrared (NIR) fluorescence provides new prospects for general and oncologic surgery. ICG is currently utilised in NIR fluorescence cancer-related surgery for three indications: sentinel lymph node (SLN) mapping, intraoperative identification of solid tumours, and angiography during reconstructive surgery. Therefore, understanding its advantages and limitations is of significant importance. Although non-targeted and non-conjugatable, ICG appears to be laying the foundation for more widespread use of NIR fluorescence-guided surgery. Copyright © 2011 Wiley-Liss, Inc.
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              Is Open Access

              A Review of Indocyanine Green Fluorescent Imaging in Surgery

              The purpose of this paper is to give an overview of the recent surgical intraoperational applications of indocyanine green fluorescence imaging methods, the basics of the technology, and instrumentation used. Well over 200 papers describing this technique in clinical setting are reviewed. In addition to the surgical applications, other recent medical applications of ICG are briefly examined.
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                Author and article information

                Journal
                The British Journal of Radiology
                BJR
                British Institute of Radiology
                0007-1285
                1748-880X
                January 2015
                January 2015
                : 88
                : 1045
                : 20140547
                Article
                10.1259/bjr.20140547
                4277384
                25410320
                © 2015

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