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      The Immune System

      journal-article
      Author(s): ,
      Other contributor(s): (Editor), (Editor)
      Publication date (Electronic):
      Publisher: Massachusetts Medical Society

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          Abstract

          New England Journal of Medicine, 343(1), 37-49

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          Most cited references45

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          Somatic generation of antibody diversity.

          Susumu Tonegawa (1983)
          In the genome of a germ-line cell, the genetic information for an immunoglobulin polypeptide chain is contained in multiple gene segments scattered along a chromosome. During the development of bone marrow-derived lymphocytes, these gene segments are assembled by recombination which leads to the formation of a complete gene. In addition, mutations are somatically introduced at a high rate into the amino-terminal region. Both somatic recombination and mutation contribute greatly to an increase in the diversity of antibody synthesized by a single organism.
          Article 0 comments Cited 560 times – based on 0 reviews     Review now
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            Innate immunity: impact on the adaptive immune response.

            R Medzhitov, C A Janeway (1997)
            For many years, innate immunity has been considered as a separate entity from the adaptive immune response and has been regarded to be of secondary importance in the hierarchy of immune functions. For the past few years, however, interest in innate immunity has grown enormously, so that now it is studied intensively in many laboratories that seek to integrate these two distinct types of immune function. Our intent in this review is to point out the similarities and differences in these two types of host response to infection, and to indicate our present level of understanding of how these can be integrated into a more complete description of the immune response.
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              Ligand recognition by alpha beta T cell receptors.

              M Davis, J. Boniface, Z Reich … (1998)
              While still incomplete, the first data concerning the biochemistry of T cell receptor-ligand interactions in cell-free systems seem to have considerable predictive value regarding whether a T cell response is strong or weak or suppressive. This data will help considerably in elucidating the mechanisms behind T cell responsiveness. Also of great interest are the first structures of T cell receptor molecules and, particularly, TCR-ligand complexes. These appear to confirm earlier suggestions of a fixed orientation for TCR engagement with peptide/MHC and should form the basis for understanding higher oligomers, evidence for which has also just emerged. We conclude with an analysis of the highly diverse CDR3 loops found in all antigen receptor molecules and suggest that such regions form the core of both TCR and antibody specificity.
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                Author and article information

                Journal
                Publisher: Massachusetts Medical Society
                Publication date (Electronic): 2000
                Publication date (Issued): 06 July 2000
                Publication date Updated: 01 August 2017
                Article
                DOI: 10.1056/NEJM200007063430107
                PubMed ID: 10882768
                SO-VID: c63c4298-5717-4220-bd34-413de7ce791b
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