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      Performance evaluation of non-ionic surfactant based tazarotene encapsulated proniosomal gel for the treatment of psoriasis.

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          Abstract

          The study aims to explore the potential of non-ionic surfactant based proniosomal gel (PNG) in improving the topical delivery of tazarotene by in vitro and in vivo studies. The PNG was prepared using coacervation phase separation method composed of span, stearylamine, cholesterol, and lecithin. The PNG demonstrated favorable vesicle size (3.26±0.22μm) and percent encapsulation efficiency (49.50±2.3%). The PNG was evaluated for viscosity which indicated that the ratio of span:cholesterol:stearylamine (64.5:30.5:5mM) demonstrated no any fluctuations in viscosity. The scanning electron micrographs exhibited spherical vesicles with sharp boundaries. The in vitro drug release through cellulose membrane and rat's skin were found to be in the following order of the formulation code A2>A4>A3>A5 and A4>A2>A3>A5, respectively, which showed the prolonged release of entrapped tazarotene. Further, in vitro drug permeation and retention studies revealed that formulations A2 and A4 showed the higher percent of drug permeation whereas formulations A3 and A5 showed the higher percent of drug retention through rat's skin. Moreover, PNG A2 and A4 formulations demonstrated good stability characteristics at different temperature conditions. The stability in the presence of detergent revealed that no any abrupt change in turbidity. The skin irritation studies performed with formulations A2 and A4 showed no erythema compared with the plain PNG. The male Albino NMRI mice tail model was used to performed in vivo skin histological examination which revealed that an increase in the orthokeratosis strengthened. Thus, all the results concluded that surfactant, Span 60 based PNG formulations have shown a good ability to increase drug accumulation in the various skin layers and more potential carrier for topical delivery of tazarotene for an effective therapy of psoriasis.

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          Author and article information

          Journal
          Mater Sci Eng C Mater Biol Appl
          Materials science & engineering. C, Materials for biological applications
          Elsevier BV
          1873-0191
          0928-4931
          Oct 01 2017
          : 79
          Affiliations
          [1 ] Research and Development, Virchow Biotech Pvt. Ltd., Survey No. 172 Part, Gagillapur (V), Quthbullapur (M), R.R. Dist, 500 043 Hyderabad, Telangana, India; Department of Pharmaceutics, School of Pharmacy, Anurag Group of Institutions, Ghatkesar-501 301 Hyderabad, Telangana, India. Electronic address: prasadvure@virchowbiotech.com.
          [2 ] Research and Development, Virchow Biotech Pvt. Ltd., Survey No. 172 Part, Gagillapur (V), Quthbullapur (M), R.R. Dist, 500 043 Hyderabad, Telangana, India.
          Article
          S0928-4931(16)30991-2
          10.1016/j.msec.2017.05.036
          28629004
          c727593e-660b-42f8-8fce-b96956482e86
          Copyright © 2017 Elsevier B.V. All rights reserved.
          History

          Topical delivery,Skin histology,Tazarotene,Proniosomes
          Topical delivery, Skin histology, Tazarotene, Proniosomes

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