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BMP-6 in renal cell carcinoma promotes tumor proliferation through IL-10-dependent M2 polarization of tumor-associated macrophages.
2013-06-15
Animals, Bone Morphogenetic Protein 6, genetics, metabolism, Carcinoma, Renal Cell, pathology, Cell Line, Cell Line, Tumor, Cell Proliferation, drug effects, Clodronic Acid, pharmacology, Doxycycline, Humans, Immunoblotting, Interleukin-10, Kaplan-Meier Estimate, Kidney Neoplasms, Macrophages, Mice, Mice, Inbred BALB C, Mice, Knockout, Microscopy, Fluorescence, RNA Interference, Reverse Transcriptase Polymerase Chain Reaction, STAT3 Transcription Factor, Smad5 Protein, Tumor Burden
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Animals,Bone Morphogenetic Protein 6,genetics,metabolism,Carcinoma, Renal Cell,pathology,Cell Line,Cell Line, Tumor,Cell Proliferation,drug effects,Clodronic Acid,pharmacology,Doxycycline,Humans,Immunoblotting,Interleukin-10,Kaplan-Meier Estimate,Kidney Neoplasms,Macrophages,Mice,Mice, Inbred BALB C,Mice, Knockout,Microscopy, Fluorescence,RNA Interference,Reverse Transcriptase Polymerase Chain Reaction,STAT3 Transcription Factor,Smad5 Protein,Tumor Burden
Animals, Bone Morphogenetic Protein 6, genetics, metabolism, Carcinoma, Renal Cell, pathology, Cell Line, Cell Line, Tumor, Cell Proliferation, drug effects, Clodronic Acid, pharmacology, Doxycycline, Humans, Immunoblotting, Interleukin-10, Kaplan-Meier Estimate, Kidney Neoplasms, Macrophages, Mice, Mice, Inbred BALB C, Mice, Knockout, Microscopy, Fluorescence, RNA Interference, Reverse Transcriptase Polymerase Chain Reaction, STAT3 Transcription Factor, Smad5 Protein, Tumor Burden