A slightly adapted treadmill protocol for the determination of maximal oxygen uptake in adults with Down syndrome

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Abstract

Introduction

The VO ₂ max test is the gold standard measure for aerobic fitness. A standardised treadmill protocol was developed years ago for individuals with Down syndrome but with variations in terms of starting speed, load increases and time spent at each stage. However, we realised that the most widely used protocol for adults with Down syndrome, trouble participants with high treadmill speeds. Consequently, the purpose of the current study was to determine whether an adapted protocol provided improved maximal test performance.

Method

Twelve adults (33 ± 6 years) randomly performed two variations of the standardised treadmill test.

Results

The protocol that added another incremental incline stage increase yielded a significant improvement in absolute and relative VO ₂ peak, time to exhaustion, minute ventilation and heart rate max.

Conclusion

A treadmill protocol with the addition of an incremental incline stage allowed for a significant improvement in maximal test performance.

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Most cited references 47

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Accelerated epigenetic aging in Down syndrome

Steve Horvath, Paolo Garagnani, Maria Bacalini … (2015)

Down Syndrome (DS) entails an increased risk of many chronic diseases that are typically associated with older age. The clinical manifestations of accelerated aging suggest that trisomy 21 increases the biological age of tissues, but molecular evidence for this hypothesis has been sparse. Here, we utilize a quantitative molecular marker of aging (known as the epigenetic clock) to demonstrate that trisomy 21 significantly increases the age of blood and brain tissue (on average by 6.6 years, P = 7.0 × 10−14).