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      double-time Is a Novel Drosophila Clock Gene that Regulates PERIOD Protein Accumulation

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      Cell

      Elsevier BV

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          Abstract

          We have isolated three alleles of a novel Drosophila clock gene, double-time (dbt). Short- (dbtS) and long-period (dbtL) mutants alter both behavioral rhythmicity and molecular oscillations from previously identified clock genes, period and timeless. A third allele, dbtP, causes pupal lethality and eliminates circadian cycling of per and tim gene products in larvae. In dbtP mutants, PER proteins constitutively accumulate, remain hypophosphorylated, and no longer depend on TIM proteins for their accumulation. We propose that the normal function of DOUBLETIME protein is to reduce the stability and thus the level of accumulation of monomeric PER proteins. This would promote a delay between per/tim transcription and PER/TIM complex function, which is essential for molecular rhythmicity.

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          Author and article information

          Journal
          Cell
          Cell
          Elsevier BV
          00928674
          July 1998
          July 1998
          : 94
          : 1
          : 83-95
          Article
          10.1016/S0092-8674(00)81224-6
          9674430
          © 1998

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