Umbilical Cord Mesenchymal Stromal Cell With Autologous Bone Marrow Cell Transplantation in Established Type 1 Diabetes: A Pilot Randomized Controlled Open-Label Clinical Study to Assess Safety and Impact on Insulin Secretion.

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Abstract

To determine the safety and effects on insulin secretion of umbilical cord (UC) mesenchymal stromal cells (MSCs) plus autologous bone marrow mononuclear cell (aBM-MNC) stem cell transplantation (SCT) without immunotherapy in established type 1 diabetes (T1D).

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Author and article information

Journal

Journal ID (iso-abbrev): Diabetes Care

Title: Diabetes care

ISSN (Electronic): 1935-5548

ISSN (Print): 0149-5992

Publication date (Electronic): Jan 2016

Volume: 39

Issue: 1

Affiliations

[1 ] Organ Transplant Institute, Fuzhou General Hospital, Xiamen University, Fuzhou, China.

[2 ] Diabetes Research Institute, Cell Transplant Center, University of Miami, Miami, FL Diabetes Research Institute Federation, Hollywood, FL The Cure Alliance, Miami, FL Department of Surgery, University of Miami Miller School of Medicine, Miami, FL.

[3 ] Diabetes Research Institute, Cell Transplant Center, University of Miami, Miami, FL Department of Medicine, University of Miami Miller School of Medicine, Miami, FL.

[4 ] Diabetes Research Institute, Cell Transplant Center, University of Miami, Miami, FL Diabetes Research Institute Federation, Hollywood, FL The Cure Alliance, Miami, FL Department of Surgery, University of Miami Miller School of Medicine, Miami, FL Department of Medicine, University of Miami Miller School of Medicine, Miami, FL.

[5 ] Organ Transplant Institute, Fuzhou General Hospital, Xiamen University, Fuzhou, China Diabetes Research Institute Federation, Hollywood, FL The Cure Alliance, Miami, FL tanjm156@xmu.edu.cn.

Article

Publisher Item ID: dc15-0171

DOI: 10.2337/dc15-0171

PubMed ID: 26628416

SO-VID: cfdc5a05-008e-406e-a233-b208cc5b3810

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