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Mosaic analysis reveals a cell-autonomous, neuronal requirement for Commissureless in the Drosophila CNS.

Development Genes and Evolution

metabolism, Membrane Proteins, physiology, Larva, Hot Temperature, Gene Expression, Drosophila Proteins, genetics, Drosophila, DNA Nucleotidyltransferases, Central Nervous System, Axons, Animals, Alleles

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      Commissureless (Comm) is a key regulator of axon guidance at the midline of the Drosophila CNS. Here we report results from mosaic analysis experiments that demonstrate a cell-autonomous, neuronal requirement for Comm. Using the MARCM system to positively label clonal patches, we find that neurons which are not deficient for Comm function make commissural projections 85% of the time. Clones of neurons that are homozygous mutant for comm make commissural projections at a statistically significant reduced frequency: 70% for comm(1), a hypomorphic mutation, and 58% for comm(5), a near null mutation. These data suggest that commissural axon guidance is dependent upon regulated expression of Comm in neurons.

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