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      Regulation of lipolysis in adipocytes.

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          Abstract

          Lipolysis of white adipose tissue triacylglycerol stores results in the liberation of glycerol and nonesterified fatty acids that are released into the vasculature for use by other organs as energy substrates. In response to changes in nutritional state, lipolysis rates are precisely regulated through hormonal and biochemical signals. These signals modulate the activity of lipolytic enzymes and accessory proteins, allowing for maximal responsiveness of adipose tissue to changes in energy requirements and availability. Recently, a number of novel adipocyte triacylglyceride lipases have been identified, including desnutrin/ATGL, greatly expanding our understanding of adipocyte lipolysis. We have also begun to better appreciate the role of a number of nonenzymatic proteins that are critical to triacylglyceride breakdown. This review provides an overview of key mediators of lipolysis and the regulation of this process by changes in nutritional status and nutrient intakes.

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          Author and article information

          Journal
          Annu Rev Nutr
          Annual review of nutrition
          Annual Reviews
          0199-9885
          0199-9885
          2007
          : 27
          Affiliations
          [1 ] Department of Nutritional Sciences and Toxicology, University of California, Berkeley, CA 94720, USA.
          Article
          NIHMS211108
          10.1146/annurev.nutr.27.061406.093734
          2885771
          17313320
          d3851a97-0679-47a6-9a67-beea107a68a3
          History

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