Sodium channel block by ranolazine in an experimental model of stretch-related atrial fibrillation: prolongation of interatrial conduction time and increase in post-repolarization refractoriness.

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Abstract

In several clinical and pre-clinical studies, application of ranolazine (RAN) led to suppression of atrial fibrillation (AF). The aim of the present study was to investigate whether RAN can suppress AF in an experimental rabbit whole heart model, in which acute haemodynamic changes trigger AF. Ranolazine was compared with flecainide and sotalol as established antiarrhythmic agents.

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Journal

Journal ID (iso-abbrev): Europace

Title: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology

Publisher: Oxford University Press (OUP)

ISSN (Electronic): 1532-2092

ISSN (Print): 1099-5129

Publication date (Electronic): May 2013

Volume: 15

Issue: 5

Affiliations

[1 ] Division of Electrophysiology, Department of Cardiovascular Medicine, University Hospital of Münster, Albert-Schweitzer Campus 1, Münster, Germany. milbergp@uni-muenster.de

Article

Publisher Item ID: eus399

DOI: 10.1093/europace/eus399

PubMed ID: 23376977

SO-VID: d44f7db7-d546-4f4e-9438-30aa5db00a49

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