We report a patient with relapsing nephrotic syndrome since the age of 4. Initial renal biopsy showed minimal change disease then focal segmental glomerulosclerosis. At the age of 21, he developed pulmonary tuberculosis, was treated with intermittent combination chemotherapy including rifampin and had oliguric acute or chronic renal failure 5 months later. Biopsy revealed crescentic membranoproliferative glomerulonephritis. The cause of the sequential glomerulonephritis is discussed.