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      Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response.

      Nature reviews. Cancer

      Animals, Cell Hypoxia, Free Radicals, Humans, Hypoxia-Inducible Factor 1, physiology, Neoplasms, blood supply, metabolism, radiotherapy, Neovascularization, Pathologic, etiology, Nitric Oxide, Oxygen, Vascular Endothelial Growth Factor A

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          Abstract

          Hypoxia and free radicals, such as reactive oxygen and nitrogen species, can alter the function and/or activity of the transcription factor hypoxia-inducible factor 1 (HIF1). Interplay between free radicals, hypoxia and HIF1 activity is complex and can influence the earliest stages of tumour development. The hypoxic environment of tumours is heterogeneous, both spatially and temporally, and can change in response to cytotoxic therapy. Free radicals created by hypoxia, hypoxia-reoxygenation cycling and immune cell infiltration after cytotoxic therapy strongly influence HIF1 activity. HIF1 can then promote endothelial and tumour cell survival. As discussed here, a constant theme emerges: inhibition of HIF1 activity will have therapeutic benefit.

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          Author and article information

          Journal
          18500244
          3943205
          10.1038/nrc2397

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