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      Steroid Pulse Therapy Combined with Tonsillectomy in IgA Nephropathy Associated with Diabetes mellitus

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          Abstract

          Ten patients with biopsy-confirmed IgA nephropathy associated with diabetes mellitus underwent dietary weight control and three courses of intravenous pulses of methylprenisolone followed by prednisolone for 6–12 months and tonsillectomy. The average length of the follow-up period was 47.8 (range 30–96) months. As compared with pretreatment values, hematuria, proteinuria, body mass index, and hemoglobin A<sub>1c</sub> were significantly improved after treatment. There were no significant differences with regard to blood pressure and glycemic blood glucose control. There was no worsening of diabetic retinopathy and nephropathy. During steroid pulse therapy, the patients who were treated with insulin needed a higher dosage of insulin; after steroid pulse therapy, the dosage returned to baseline. Even patients with IgA nephropathy and diabetes mellitus could be treated with combined therapy and showed beneficial responses, it they succeeded in reducing body mass index.

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          Most cited references 3

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          Hypertension and associated metabolic abnormalities--the role of insulin resistance and the sympathoadrenal system.

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            Corticosteroids in IgA nephropathy: a randomised controlled trial

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              Urinary macrophage counts and ratio to T lymphocytes: Possible use in differential diagnosis and management of glomerular disease

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                Author and article information

                Journal
                NEF
                Nephron
                10.1159/issn.1660-8151
                Nephron
                S. Karger AG
                1660-8151
                2235-3186
                2001
                2001
                22 November 2001
                : 89
                : 4
                : 398-401
                Affiliations
                Department of Nephrology, Sendai Shakaihoken Hospital, Sendai, Japan
                Article
                46110 Nephron 2001;89:398–401
                10.1159/000046110
                11721156
                © 2001 S. Karger AG, Basel

                Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

                Page count
                Tables: 2, References: 9, Pages: 4
                Product
                Self URI (application/pdf): https://www.karger.com/Article/Pdf/46110
                Categories
                Original Paper

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