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Lipid rafts and signal transduction.

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Nature reviews. Molecular cell biology

Springer Nature

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      Abstract

      Signal transduction is initiated by complex protein-protein interactions between ligands, receptors and kinases, to name only a few. It is now becoming clear that lipid micro-environments on the cell surface -- known as lipid rafts -- also take part in this process. Lipid rafts containing a given set of proteins can change their size and composition in response to intra- or extracellular stimuli. This favours specific protein-protein interactions, resulting in the activation of signalling cascades.

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      Affiliations
      [1 ] Max Planck Institute for Molecular Cell Biology and Genetics, Pfotenhauerstrasse 110, D-01307 Dresden, Germany. Simons@EMBL-Heidelberg.de
      Journal
      Nat. Rev. Mol. Cell Biol.
      Nature reviews. Molecular cell biology
      Springer Nature
      1471-0072
      1471-0072
      Oct 2000
      : 1
      : 1
      11413487
      10.1038/35036052
      35036052

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