Evaluation of the Relationship Between Diabetic Macular Edema and Renal Function in a Latino Population

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

Introduction

Diabetic macular edema (DME) is one of the leading causes of vision impairment. The relationship between DME and estimated glomerular filtration rate (eGFR) has not been clearly evaluated in Hispanic or Latino populations. The objective of this study was to evaluate the eGFR in a Latino population with DME.

Methods

A cross-sectional, observational, and descriptive study was carried out on the basis of a multicenter phase III clinical trial.

Results

A total of 82 subjects diagnosed with DME (36 women and 46 men) were included in the study. The mean age was 61.93 ± 6.71 years. Mean values of the blood chemistry parameters glycated hemoglobin and eGFR were 7.20 ± 0.95% and 74.42 ± 26.82 mL/min/1.73 m ², respectively. The time elapsed since diagnosis of diabetes mellitus was 15.30 ± 7.35 years, while the duration of DME was 1.41 ± 1.75 years. Mean values for central macular thickness (CMT) and total macular volume (TMV) were 440.99 ± 132.22 µm and 11.97 ± 2.11 mm ³, respectively. DME duration had a negative correlation with TMV (Rho − 0.26, p < 0.05) and a positive correlation with mean arterial pressure (Rho 0.26, p < 0.05). CMT was correlated with TMV (Rho 0.43, p < 0.0001) and visual acuity (Rho 0.26, p < 0.05). No significant correlations were observed between eGFR and CMT, TMV, or any demographic variable ( p > 0.05). Chronic kidney disease (CKD) was associated with hypertension (OR 9.32, p = 0.035), elevated intraocular pressure (IOP) (OR 0.03, p = 0.011), and advanced age (OR 0.45, p = 0.011). CMT was significantly associated with TMV ( β = 27.69, p < 0.0001).

Conclusions

We did not find a correlation between eGFR and DME. Our findings suggest that the presence of hypertension is associated with a decrease in the GFR < 60 mL/min/1.73 m ², and CKD may be associated with advanced age and elevated IOP which may increase the risk for the development of glaucoma.

Trial Registration

NCT05217680 (clinicaltrials.gov).

Supplementary Information

The online version contains supplementary material available at 10.1007/s40123-023-00787-w.

Related collections

Most cited references 44

Record: found
Abstract: found
Article: not found

Correlation Coefficients

Patrick Schober, Christa Boer, Lothar A Schwarte (2018)

Correlation in the broadest sense is a measure of an association between variables. In correlated data, the change in the magnitude of 1 variable is associated with a change in the magnitude of another variable, either in the same (positive correlation) or in the opposite (negative correlation) direction. Most often, the term correlation is used in the context of a linear relationship between 2 continuous variables and expressed as Pearson product-moment correlation. The Pearson correlation coefficient is typically used for jointly normally distributed data (data that follow a bivariate normal distribution). For nonnormally distributed continuous data, for ordinal data, or for data with relevant outliers, a Spearman rank correlation can be used as a measure of a monotonic association. Both correlation coefficients are scaled such that they range from -1 to +1, where 0 indicates that there is no linear or monotonic association, and the relationship gets stronger and ultimately approaches a straight line (Pearson correlation) or a constantly increasing or decreasing curve (Spearman correlation) as the coefficient approaches an absolute value of 1. Hypothesis tests and confidence intervals can be used to address the statistical significance of the results and to estimate the strength of the relationship in the population from which the data were sampled. The aim of this tutorial is to guide researchers and clinicians in the appropriate use and interpretation of correlation coefficients.

0 comments Cited 1290 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: found
Article: not found

Chronic Kidney Disease.

Angela Webster, Evi V Nagler, Rachael Morton … (2017)

The definition and classification of chronic kidney disease (CKD) have evolved over time, but current international guidelines define this condition as decreased kidney function shown by glomerular filtration rate (GFR) of less than 60 mL/min per 1·73 m(2), or markers of kidney damage, or both, of at least 3 months duration, regardless of the underlying cause. Diabetes and hypertension are the main causes of CKD in all high-income and middle-income countries, and also in many low-income countries. Incidence, prevalence, and progression of CKD also vary within countries by ethnicity and social determinants of health, possibly through epigenetic influence. Many people are asymptomatic or have non-specific symptoms such as lethargy, itch, or loss of appetite. Diagnosis is commonly made after chance findings from screening tests (urinary dipstick or blood tests), or when symptoms become severe. The best available indicator of overall kidney function is GFR, which is measured either via exogenous markers (eg, DTPA, iohexol), or estimated using equations. Presence of proteinuria is associated with increased risk of progression of CKD and death. Kidney biopsy samples can show definitive evidence of CKD, through common changes such as glomerular sclerosis, tubular atrophy, and interstitial fibrosis. Complications include anaemia due to reduced production of erythropoietin by the kidney; reduced red blood cell survival and iron deficiency; and mineral bone disease caused by disturbed vitamin D, calcium, and phosphate metabolism. People with CKD are five to ten times more likely to die prematurely than they are to progress to end stage kidney disease. This increased risk of death rises exponentially as kidney function worsens and is largely attributable to death from cardiovascular disease, although cancer incidence and mortality are also increased. Health-related quality of life is substantially lower for people with CKD than for the general population, and falls as GFR declines. Interventions targeting specific symptoms, or aimed at supporting educational or lifestyle considerations, make a positive difference to people living with CKD. Inequity in access to services for this disease disproportionally affects disadvantaged populations, and health service provision to incentivise early intervention over provision of care only for advanced CKD is still evolving in many countries.

0 comments Cited 865 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: found
Article: not found

Global burden of hypertension: analysis of worldwide data.

Patricia Kearney, Megan Whelton, Kristi Reynolds … (2005)

Reliable information about the prevalence of hypertension in different world regions is essential to the development of national and international health policies for prevention and control of this condition. We aimed to pool data from different regions of the world to estimate the overall prevalence and absolute burden of hypertension in 2000, and to estimate the global burden in 2025. We searched the published literature from Jan 1, 1980, to Dec 31, 2002, using MEDLINE, supplemented by a manual search of bibliographies of retrieved articles. We included studies that reported sex-specific and age-specific prevalence of hypertension in representative population samples. All data were obtained independently by two investigators with a standardised protocol and data-collection form. Overall, 26.4% (95% CI 26.0-26.8%) of the adult population in 2000 had hypertension (26.6% of men [26.0-27.2%] and 26.1% of women [25.5-26.6%]), and 29.2% (28.8-29.7%) were projected to have this condition by 2025 (29.0% of men [28.6-29.4%] and 29.5% of women [29.1-29.9%]). The estimated total number of adults with hypertension in 2000 was 972 million (957-987 million); 333 million (329-336 million) in economically developed countries and 639 million (625-654 million) in economically developing countries. The number of adults with hypertension in 2025 was predicted to increase by about 60% to a total of 1.56 billion (1.54-1.58 billion). Hypertension is an important public-health challenge worldwide. Prevention, detection, treatment, and control of this condition should receive high priority.

0 comments Cited 675 times – based on 0 reviews      Review now

Bookmark

All references

Author and article information

Contributors

Patricia Muñoz-Villegas:

ORCID: http://orcid.org/0000-0002-7559-1218

patricia.munoz@sophia.com.mx

Journal

Journal ID (nlm-ta): Ophthalmol Ther

Journal ID (iso-abbrev): Ophthalmol Ther

Title: Ophthalmology and Therapy

Publisher: Springer Healthcare (Cheshire )

ISSN (Print): 2193-8245

ISSN (Electronic): 2193-6528

Publication date (Electronic): 6 August 2023

Publication date PMC-release: 6 August 2023

Publication date (Print): October 2023

Volume: 12

Issue: 5

Pages: 2745-2755

Affiliations

[1 ]GRID grid.487303.b, ISNI 0000 0004 0621 5571, Regional Medical Affairs Department, , Laboratorios Sophia, S.A. de C.V., ; Paseo del Norte 5255, Guadalajara Technology Park, 45010 Zapopan, JAL Mexico

[2 ]GRID grid.412890.6, ISNI 0000 0001 2158 0196, Instituto de Investigación en Oftalmología y Ciencias Visuales, CUCS, University of Guadalajara, ; Sierra Mojada 950, 44340 Guadalajara, JAL Mexico

[3 ]GRID grid.454267.6, Centro de Investigación en Matemáticas (CIMAT), , Unidad Aguascalientes, ; Aguascalientes, Mexico

Author information

Patricia Muñoz-Villegas http://orcid.org/0000-0002-7559-1218

Article

Publisher ID: 787

DOI: 10.1007/s40123-023-00787-w

PMC ID: 10441930

PubMed ID: 37543959

SO-VID: da0d7f17-c3e6-4513-b192-b3dc975c158c

License:

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/.

History

Date received : 11 July 2023

Date accepted : 28 July 2023

Funding

Funded by: Laboratorios Sophia, SA de CV

Custom metadata

Keywords: central macular thickness,total macular volume,diabetes mellitus,diabetic macular edema,glomerular filtration rate

Data availability:

Keywords: central macular thickness, total macular volume, diabetes mellitus, diabetic macular edema, glomerular filtration rate

Evaluation of the Relationship Between Diabetic Macular Edema and Renal Function in a Latino Population

Read this article at

Abstract

Introduction

Methods

Results

Conclusions

Trial Registration

Supplementary Information

Related collections

The Journal of Population and Sustainability

Most cited references 44

Correlation Coefficients

Chronic Kidney Disease.

Global burden of hypertension: analysis of worldwide data.

Author and article information

Contributors

Journal

Affiliations

Author information

Article

History

Funding

Categories

Custom metadata

Comments

Comment on this article

Similar content 187

Most referenced authors 674