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      The Taverna workflow suite: designing and executing workflows of Web Services on the desktop, web or in the cloud

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          Abstract

          The Taverna workflow tool suite ( http://www.taverna.org.uk) is designed to combine distributed Web Services and/or local tools into complex analysis pipelines. These pipelines can be executed on local desktop machines or through larger infrastructure (such as supercomputers, Grids or cloud environments), using the Taverna Server. In bioinformatics, Taverna workflows are typically used in the areas of high-throughput omics analyses (for example, proteomics or transcriptomics), or for evidence gathering methods involving text mining or data mining. Through Taverna, scientists have access to several thousand different tools and resources that are freely available from a large range of life science institutions. Once constructed, the workflows are reusable, executable bioinformatics protocols that can be shared, reused and repurposed. A repository of public workflows is available at http://www.myexperiment.org. This article provides an update to the Taverna tool suite, highlighting new features and developments in the workbench and the Taverna Server.

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          Most cited references27

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          Gapped BLAST and PSI-BLAST: a new generation of protein database search programs.

          S Altschul (1997)
          The BLAST programs are widely used tools for searching protein and DNA databases for sequence similarities. For protein comparisons, a variety of definitional, algorithmic and statistical refinements described here permits the execution time of the BLAST programs to be decreased substantially while enhancing their sensitivity to weak similarities. A new criterion for triggering the extension of word hits, combined with a new heuristic for generating gapped alignments, yields a gapped BLAST program that runs at approximately three times the speed of the original. In addition, a method is introduced for automatically combining statistically significant alignments produced by BLAST into a position-specific score matrix, and searching the database using this matrix. The resulting Position-Specific Iterated BLAST (PSI-BLAST) program runs at approximately the same speed per iteration as gapped BLAST, but in many cases is much more sensitive to weak but biologically relevant sequence similarities. PSI-BLAST is used to uncover several new and interesting members of the BRCT superfamily.
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            Galaxy: a comprehensive approach for supporting accessible, reproducible, and transparent computational research in the life sciences

            Increased reliance on computational approaches in the life sciences has revealed grave concerns about how accessible and reproducible computation-reliant results truly are. Galaxy http://usegalaxy.org, an open web-based platform for genomic research, addresses these problems. Galaxy automatically tracks and manages data provenance and provides support for capturing the context and intent of computational methods. Galaxy Pages are interactive, web-based documents that provide users with a medium to communicate a complete computational analysis.
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              Update on activities at the Universal Protein Resource (UniProt) in 2013

              The mission of the Universal Protein Resource (UniProt) (http://www.uniprot.org) is to support biological research by providing a freely accessible, stable, comprehensive, fully classified, richly and accurately annotated protein sequence knowledgebase. It integrates, interprets and standardizes data from numerous resources to achieve the most comprehensive catalogue of protein sequences and functional annotation. UniProt comprises four major components, each optimized for different uses, the UniProt Archive, the UniProt Knowledgebase, the UniProt Reference Clusters and the UniProt Metagenomic and Environmental Sequence Database. UniProt is produced by the UniProt Consortium, which consists of groups from the European Bioinformatics Institute (EBI), the SIB Swiss Institute of Bioinformatics (SIB) and the Protein Information Resource (PIR). UniProt is updated and distributed every 4 weeks and can be accessed online for searches or downloads.
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                Author and article information

                Journal
                Nucleic Acids Res
                Nucleic Acids Res
                nar
                nar
                Nucleic Acids Research
                Oxford University Press
                0305-1048
                1362-4962
                July 2013
                2 May 2013
                2 May 2013
                : 41
                : Web Server issue
                : W557-W561
                Affiliations
                1School of Computer Science, University of Manchester, Manchester, M13 9PL, UK, 2Astrazeneca, Alderly Park, Macclesfield, SK10 4TF, UK, 3Computer Science and Informatics, Cardiff University, Roath, Cardiff, CF24 3AA, UK and 4Faculty of Science, University of Amsterdam, 1098 XH Amsterdam, The Netherlands
                Author notes
                *To whom correspondence should be addressed. Tel: +44 161 275 6276; Fax: +44 161 275 6236; Email: katherine.wolstencroft@ 123456manchester.ac.uk
                Article
                gkt328
                10.1093/nar/gkt328
                3692062
                23640334
                dda8bfe3-84a1-46f2-9671-d77cd496e503
                © The Author(s) 2013. Published by Oxford University Press.

                This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/3.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                : 31 January 2013
                : 28 March 2013
                : 9 April 2013
                Page count
                Pages: 5
                Categories
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                Custom metadata
                1 July 2013

                Genetics
                Genetics

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