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      • Record: found
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      The rate of hypercapnic respiratory failure in a pulmonary function test laboratory database

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      Author(s): 1 , 2 , , 2 , 1
      Publication date (Electronic):
      Journal: ERJ Open Research
      Publisher: European Respiratory Society

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          Chronic hypercapnic respiratory failure (CHRF) may occur in advanced stages of COPD. The prevalence of CHRF due to any causes in the general population ranges from 0.08% in in 45- to 54-year-old individuals to 1.7% in those aged >85 years [1]. In patients with COPD, the prevalence of CHRF is not well studied. The aim of this study was to estimate the rate of CHRF in individuals with various spirometric categories and various degrees of lung function impairment.

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          Hypercapnia rates are in the range 3.6–12% among those with abnormal spirometry and FEV 1 ≥80% pred, and 53–58% among those with FEV 1 <35% pred. Both airflow obstruction and preserved ratio impaired spirometry are associated with higher risk of CHRF. https://bit.ly/3H8DlfM

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          Effect of Home Noninvasive Ventilation With Oxygen Therapy vs Oxygen Therapy Alone on Hospital Readmission or Death After an Acute COPD Exacerbation : A Randomized Clinical Trial

          Patrick B. Murphy, Sunita Rehal, Gill Arbane … (2017)
          Outcomes after exacerbations of chronic obstructive pulmonary disease (COPD) requiring acute noninvasive ventilation (NIV) are poor and there are few treatments to prevent hospital readmission and death.
          Article 0 comments Cited 179 times – based on 0 reviews     Review now
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            Non-invasive positive pressure ventilation for the treatment of severe stable chronic obstructive pulmonary disease: a prospective, multicentre, randomised, controlled clinical trial.

            Thomas Köhnlein, Wolfram Windisch, Dieter Köhler … (2014)
            Evidence is weak for the ability of long-term non-invasive positive pressure ventilation (NPPV) to improve survival in patients with stable hypercapnic chronic obstructive pulmonary disease (COPD). Previous prospective studies did not target a reduction in hypercapnia when adjusting ventilator settings. This study investigated the effect of long-term NPPV, targeted to markedly reduce hypercapnia, on survival in patients with advanced, stable hypercapnic COPD.
            Article 0 comments Cited 120 times – based on 0 reviews     Review now
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              Readmission rates and life threatening events in COPD survivors treated with non-invasive ventilation for acute hypercapnic respiratory failure.

              Alvin Lai, Victoria Wong, Derek V Chan … (2004)
              Non-invasive ventilation (NIV) has been shown to reduce intubation and in-hospital mortality in patients with chronic obstructive pulmonary disease (COPD) and acute hypercapnic respiratory failure (AHRF). However, little information exists on the outcomes following discharge. A study was undertaken to examine the rates of readmission, recurrent AHRF, and death following discharge and the risk factors associated with them. A cohort of COPD patients with AHRF who survived after treatment with NIV in a respiratory high dependency unit was prospectively followed from July 2001 to October 2002. The times to readmission, first recurrent AHRF, and death were recorded and analysed against potential risk factors collected during the index admission. One hundred and ten patients (87 men) of mean (SD) age 73.2 (7.6) years survived AHRF after NIV during the study period. One year after discharge 79.9% had been readmitted, 63.3% had another life threatening event, and 49.1% had died. Survivors spent a median of 12% of the subsequent year in hospital. The number of days in hospital in the previous year (p = 0.016) and a low Katz score (p = 0.018) predicted early readmission; home oxygen use (p = 0.002), APACHE II score (p = 0.006), and a lower body mass index (p = 0.041) predicted early recurrent AHRF or death; the MRC dyspnoea score (p<0.001) predicted early death. COPD patients with AHRF who survive following treatment with NIV have a high risk of readmission and life threatening events. Further studies are urgently needed to devise strategies to reduce readmission and life threatening events in this group of patients.
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                Author and article information

                Journal
                Journal ID (nlm-ta): ERJ Open Res
                Journal ID (iso-abbrev): ERJ Open Res
                Journal ID (publisher-id): ERJOR
                Journal ID (hwp): erjor
                Title: ERJ Open Research
                Publisher: European Respiratory Society
                ISSN (Electronic): 2312-0541
                Publication date Collection: March 2024
                Publication date (Electronic): 18 March 2024
                Volume: 10
                Issue: 2
                Electronic Location Identifier: 01016-2023
                Affiliations
                [1 ]Division of Pulmonary, Critical Care and Occupational Medicine, University of Iowa Hospital & Clinics, Iowa City, IA, USA
                [2 ]Center for Access and Delivery Research and Evaluation, Iowa City VA Health Care System, Iowa City, IA, USA
                Author notes
                Author information
                https://orcid.org/0000-0003-1521-7520
                Article
                Publisher ID: 01016-2023
                DOI: 10.1183/23120541.01016-2023
                PMC ID: 10945382
                PubMed ID: 38500793
                SO-VID: df09d2a1-b46f-4b0e-9377-3856eeea6d21
                Copyright © Copyright ©The authors 2024
                License:

                This version is distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0. For commercial reproduction rights and permissions contact permissions@ 123456ersnet.org

                History
                Date received : 12 November 2023
                Date accepted : 03 January 2024
                Categories
                Subject: Research Letters
                Subject: 10

                Data availability:

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