There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.
Abstract
Cultured glial cells from the cerebellum of 15-day-old taiep rats produced NO, increased
iNOS levels, up-regulated iNOS expression and promoted TNF release when stimulated
with LPS and IFNgamma. These responses were much greater than in control cells. In
taiep glial cells, NO production and iNOS levels and expression induced by the co-stimulatory
signal were resistant to the inhibitory effect of TGFbeta1. The glial cell priming
might have been generated by oligodendrocyte alteration in taiep rats.