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NF-kappaB activation and overexpression of regulated genes in human diabetic nephropathy.
Sergio Mezzano
1 ,
Claudio Aros ,
Alejandra Droguett ,
M Eugenia Burgos ,
Leopoldo Ardiles ,
Claudio Flores ,
Herman Schneider ,
Marta Ruiz-Ortega ,
Jesús Egido
Oct 2004
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Abstract
Nuclear factor-kappaB (NF-kappaB) regulates genes involved in renal disease progression, such as the chemokines monocyte chemoattractant protein-1 (MCP-1) and RANTES. NF-kappaB is activated in experimental models of renal injury, and in vitro studies also suggest that proteinuria and angiotensin II could be important NF-kappaB activators. It has been proposed that locally produced MCP-1 may be involved in the development of diabetic nephropathy (DN). We examined the hypothesis that NF-kappaB could be an indicator of renal damage progression in DN.