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      Legionella pneumophila as Cause of Severe Community-Acquired Pneumonia, China

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          Abstract

          We report a case of community-acquired pneumonia in a patient in China. We verified Legionella pneumophila infection through next-generation sequencing of blood, sputum, and pleural effusion samples. Our results show the usefulness of next-generation sequencing and of testing different samples early in the course of illness to identify this bacterium.

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          Most cited references7

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          Microbiological Diagnostic Performance of Metagenomic Next-generation Sequencing When Applied to Clinical Practice

          Metagenomic next-generation sequencing (mNGS) was suggested to potentially replace traditional microbiological methodology because of its comprehensiveness. However, clinical experience with application of the test is relatively limited.
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            Community-acquired pneumonia

            Summary Community-acquired pneumonia causes great mortality and morbidity and high costs worldwide. Empirical selection of antibiotic treatment is the cornerstone of management of patients with pneumonia. To reduce the misuse of antibiotics, antibiotic resistance, and side-effects, an empirical, effective, and individualised antibiotic treatment is needed. Follow-up after the start of antibiotic treatment is also important, and management should include early shifts to oral antibiotics, stewardship according to the microbiological results, and short-duration antibiotic treatment that accounts for the clinical stability criteria. New approaches for fast clinical (lung ultrasound) and microbiological (molecular biology) diagnoses are promising. Community-acquired pneumonia is associated with early and late mortality and increased rates of cardiovascular events. Studies are needed that focus on the long-term management of pneumonia.
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              Legionella spp. and Legionnaires' disease.

              Infection with Legionella spp. is an important cause of community- and hospital-acquired pneumonia, occurring both sporadically and in outbreaks. Infection with Legionella spp. ranks among the three most common causes of severe pneumonia in the community setting, and is isolated in 1-40% of cases of hospital-acquired pneumonia. There are no clinical features unique to Legionnaires' disease. Macrolides and fluoroquinolones are the most widely used drugs in treatment. The availability of a good diagnostic repertoire, suitable for accurately diagnosing LD, constitutes the basis for the early recognition and treatment of the individual patient as well as for effective measures for prevention and control. This review summarizes the available information regarding the microbiology, clinical presentation, diagnosis and treatment of LD, with an emphasis on the laboratory diagnosis of infection with Legionella spp.
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                Author and article information

                Journal
                Emerg Infect Dis
                Emerging Infect. Dis
                EID
                Emerging Infectious Diseases
                Centers for Disease Control and Prevention
                1080-6040
                1080-6059
                January 2020
                : 26
                : 1
                : 160-162
                Affiliations
                [1]Ruijin Hospital, Shanghai, China
                Author notes
                Address for correspondence: Min Zhou, Ruijin Hospital, Shanghai Jiao Tong University Medical School Affiliated, Department of Respiratory and Critical Care Medicine, No. 197 Ruijin Er Rd, Shanghai, 200025, China; email: doctor_zhou_99@ 123456163.com
                Article
                19-0655
                10.3201/eid2601.190655
                6924908
                31855541
                e2422c5a-527a-4a8f-8460-85476ba60b86
                History
                Categories
                Research Letter
                Research Letter
                Legionella pneumophila as Cause of Severe Community-Acquired Pneumonia, China

                Infectious disease & Microbiology
                community-acquired pneumonia,pneumonia,legionella pneumophila,next-generation sequencing,bacteria,respiratory infections,china

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