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      The biogenesis of lysosomes: is it a kiss and run, continuous fusion and fission process?

      Bioessays

      Antigens, CD, metabolism, Cathepsin D, Cell Compartmentation, Endosomes, physiology, Eukaryotic Cells, ultrastructure, Golgi Apparatus, Hydrogen-Ion Concentration, Lysosome-Associated Membrane Glycoproteins, Lysosomes, Membrane Fusion, Membrane Glycoproteins, Models, Biological

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          Abstract

          Molecules are transferred to lysosomes, the major, acid pH, digestive compartment in eukaryotic cells, by a complex series of pathways that converge at a late endosome/prelysosomal compartment. Here, we discuss the relationship between this compartment and the lysosome. We propose that lysosomes are maintained within cells by a repeated series of kiss and run, transient fusion and fission processes with the late endosome/prelysosome compartment. Directionality to these processes may be conferred by pH gradients and retrieval mechanisms. The future challenge in testing this and any other proposed hypothesis for lysosomal biogenesis will be the establishment of molecular mechanisms.

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          Journal
          8939067
          10.1002/bies.950181108

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