For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
24
views
28
references
 Top references
cited by
65
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
0 collections
    0
    shares
      3,750
      similar
       All similar
      • Record: found
      • Abstract: not found
      • Article: not found

      Role of Donor Clonal Hematopoiesis in Allogeneic Hematopoietic Stem-Cell Transplantation

      Author(s): 1 , 1 , 1 , 1 , 1 , 1 , 1 , 1 , 1 , 1 , 1 , 1 , 1 , 1 , 1 , 1 , 1 , 1 , 1 , 1 , 1 , 1 , 1 , 1 , 1 , 1 , 1 , 1 , 1 , 1 , 1 , 1 , 1 , 1 , 1 , 1 , 1 , 1
      Publication date Created:
      Publication date (Electronic):
      Journal: Journal of Clinical Oncology
      Publisher: American Society of Clinical Oncology (ASCO)

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Clonal hematopoiesis of indeterminate potential (CHIP) occurs in the blood of approximately 20% of older persons. CHIP is linked to an increased risk of hematologic malignancies and of all-cause mortality; thus, the eligibility of stem-cell donors with CHIP is questionable. We comprehensively investigated how donor CHIP affects outcome of allogeneic hematopoietic stem-cell transplantation (HSCT).

          Related collections

          Most cited references28

          • Record: found
          • Abstract: not found
          • Article: not found

          Pathophysiology of Chronic Graft-versus-Host Disease and Therapeutic Targets

          Robert Zeiser, Bruce R. Blazar, Dan L Longo (2017)
          Article 0 comments Cited 231 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: found
            • Article: found
            Is Open Access

            Leukemia-Associated Somatic Mutations Drive Distinct Patterns of Age-Related Clonal Hemopoiesis

            Thomas McKerrell, Naomi Park, Thaidy Moreno … (2015)
            Summary Clonal hemopoiesis driven by leukemia-associated gene mutations can occur without evidence of a blood disorder. To investigate this phenomenon, we interrogated 15 mutation hot spots in blood DNA from 4,219 individuals using ultra-deep sequencing. Using only the hot spots studied, we identified clonal hemopoiesis in 0.8% of individuals under 60, rising to 19.5% of those ≥90 years, thus predicting that clonal hemopoiesis is much more prevalent than previously realized. DNMT3A-R882 mutations were most common and, although their prevalence increased with age, were found in individuals as young as 25 years. By contrast, mutations affecting spliceosome genes SF3B1 and SRSF2, closely associated with the myelodysplastic syndromes, were identified only in those aged >70 years, with several individuals harboring more than one such mutation. This indicates that spliceosome gene mutations drive clonal expansion under selection pressures particular to the aging hemopoietic system and explains the high incidence of clonal disorders associated with these mutations in advanced old age.
            Article 0 comments Cited 198 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Somatic Mutations and Clonal Hematopoiesis in Aplastic Anemia.

              Tetsuichi Yoshizato, Bogdan Dumitriu, Kohei Hosokawa … (2015)
              In patients with acquired aplastic anemia, destruction of hematopoietic cells by the immune system leads to pancytopenia. Patients have a response to immunosuppressive therapy, but myelodysplastic syndromes and acute myeloid leukemia develop in about 15% of the patients, usually many months to years after the diagnosis of aplastic anemia.
              Article 0 comments Cited 175 times – based on 0 reviews     Review now
                Bookmark
                All references

                Author and article information

                Journal
                Title: Journal of Clinical Oncology
                Abbreviated Title: JCO
                Publisher: American Society of Clinical Oncology (ASCO)
                ISSN (Print): 0732-183X
                ISSN (Electronic): 1527-7755
                Publication date Created: November 07 2018
                Publication date (Electronic): November 07 2018
                Page: JCO.2018.79.218
                Affiliations
                [1 ]Mareike Frick, Willy Chan, Christopher Maximilian Arends, Raphael Hablesreiter, Adriane Halik, Olga Blau, Kaja Hoyer, Friederike Christen, Joel Galan-Sousa, Daniel Noerenberg, Igor Wolfgang Blau, Armin Gerbitz, Lars Bullinger, and Frederik Damm, Charité - University Medical Center Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health; Tomasz Zemojtel, Berlin Institute of Health (BIH) Core Genomics Facility, Charité, University Medical Center,...
                Article
                DOI: 10.1200/JCO.2018.79.2184
                PubMed ID: 30403573
                SO-VID: e6456e29-0aa4-4ec0-8ad3-008d1c928be8
                Copyright © © 2018
                History

                Data availability:

                Comments

                Comment on this article

                scite_

                Similar content3,750

                See all similar

                Cited by65

                See all cited by

                Most referenced authors1,442

                See all reference authors