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      Eltrombopag Added to Immunosuppression in Severe Aplastic Anemia

      Author(s): 1 , 1 , 1 , 1 , 1 , 1 , 1 , 1 , 1 , 1 , 1 , 1 , 1 , 1 , 1 , 1 , 1 , 1 , 1 , 1 , 1 , 1 , 1 , 1 , 1 , 1 , 1 , 1 , 1 , 1 , 1 , 1 , 1 , 1 , 1 , 1 , 1 , 1 , 1 , 1 , 1 , 1 , 1 , 1 , 1 , 1 , 1 , 1 , 1 , 1
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      Journal: New England Journal of Medicine
      Publisher: Massachusetts Medical Society

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          Aplastic Anemia

          Dan L Longo, Neal Young (2018)
          Article 0 comments Cited 225 times – based on 0 reviews     Review now
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            Somatic Mutations and Clonal Hematopoiesis in Aplastic Anemia.

            Tetsuichi Yoshizato, Bogdan Dumitriu, Kohei Hosokawa … (2015)
            In patients with acquired aplastic anemia, destruction of hematopoietic cells by the immune system leads to pancytopenia. Patients have a response to immunosuppressive therapy, but myelodysplastic syndromes and acute myeloid leukemia develop in about 15% of the patients, usually many months to years after the diagnosis of aplastic anemia.
            Article 0 comments Cited 175 times – based on 0 reviews     Review now
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              Eltrombopag Added to Standard Immunosuppression for Aplastic Anemia.

              Danielle M Townsley, Phillip Scheinberg, Thomas Winkler … (2017)
              Acquired aplastic anemia results from immune-mediated destruction of bone marrow. Immunosuppressive therapies are effective, but reduced numbers of residual stem cells may limit their efficacy. In patients with aplastic anemia that was refractory to immunosuppression, eltrombopag, a synthetic thrombopoietin-receptor agonist, led to clinically significant increases in blood counts in almost half the patients. We combined standard immunosuppressive therapy with eltrombopag in previously untreated patients with severe aplastic anemia.
              Article 0 comments Cited 110 times – based on 0 reviews     Review now
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                Author and article information

                Contributors
                Ursula La Rocca: (View ORCID Profile)
                Journal
                Title: New England Journal of Medicine
                Abbreviated Title: N Engl J Med
                Publisher: Massachusetts Medical Society
                ISSN (Print): 0028-4793
                ISSN (Electronic): 1533-4406
                Publication date Created: January 06 2022
                Publication date (Print): January 06 2022
                Volume: 386
                Issue: 1
                Pages: 11-23
                Affiliations
                [1 ]From the French Reference Center for Aplastic Anemia and Paroxysmal Nocturnal Hemoglobinuria, Saint-Louis Hospital and Université de Paris (R.P.L., F.S.F., C.F., G.S.), and the Adolescent and Young Adult Hematology Unit, Saint-Louis Hospital (F.R.), Paris, the Hematology Department, Centre Hospitalier Universitaire de Toulouse, Institut Universitaire du Cancer de Toulouse Oncopole, Toulouse (C.R., S.T.), Centre Hospitalier Universitaire Lyon Sud, Lyon (F.B., A.P.), Centre Hospitalier Universitaire de...
                Article
                DOI: 10.1056/NEJMoa2109965
                PubMed ID: 34986284
                SO-VID: 5c179002-e5af-4e03-b4f3-aa9536238e42
                Copyright © © 2022
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                http://www.nejmgroup.org/legal/terms-of-use.htm

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