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      Associations of the PON1 rs854560 polymorphism with plasma lipid levels: a meta-analysis

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          Abstract

          Background

          Previous studies have investigated the associations of paraoxonase 1 ( PON1) rs854560 polymorphism with plasma lipid levels, but the results are inconclusive. This meta-analysis aimed to clarify the associations of the rs854560 polymorphism with plasma lipid levels.

          Methods

          A comprehensive search of the literature was carried out by using the databases which include Medline, Google Scholar, Web of Science, Embase, Cochrane Library, China National Knowledge Infrastructure (CNKI), Wanfang and VIP database up till August 2018. The pooled standardized mean difference (SMD) with 95% confidence interval (CI) was used to assess the differences in lipid levels between the genotypes. Begg’s funnel plots and Egger’s test were used to examine the publication bias.

          Results

          A total of 41 studies (22,844 subjects) were identified for the associations of rs854560 polymorphism with plasma lipid levels. The M carriers had lower levels of high-density lipoprotein Cholesterol (HDL-C) (SMD = − 0.15, 95% CI = − 0.23--0.07, P < 0.01) and apolipoprotein A-I (APOA1) (SMD = − 0.67, 95% CI = − 0.93--0.41, P < 0.01) than the non-carriers. Subgroup analysis by ethnicity revealed that the effect on HDL level was significant in Caucasians and the subjects of other ethnic origins. No publication bias was detected in this meta-analysis.

          Conclusions

          The meta-analysis suggests that the PON1 rs854560 polymorphism is associated with a lower HDL-C level in Caucasians and subjects of other ethnic origins.

          Electronic supplementary material

          The online version of this article (10.1186/s12944-018-0924-0) contains supplementary material, which is available to authorized users.

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          Most cited references26

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          The assessment of carotid intima media thickness and serum Paraoxonase-1 activity in Helicobacter pylori positive subjects

          Halide S Akbas, Sebahat Basyigit, Inci Suleymanlar … (2010)
          Background The role of inflammation in the pathogenesis and progression of atherosclerosis has been increasingly discussed. Although the seroepidemiological studies have suggested a relationship between Helicobacter pylori (H. pylori) infection and atherosclerosis; the issue is still controversial. It is well known that abnormal lipid profil is related to atherosclerosis and the measurement of carotid-intima media thickness (CIMT) is one of the surrogate marker of atherosclerosis. The serum concentration of high-density lipoprotein (HDL-C) has been known to have an inverse correlation with the development of atherosclerosis. Paraoxonase-1 (PON1) is a major anti-atherosclerotic component of HDL-C. PON1 activity is related to lipid peroxidation and prospective cardiovascular risk. The aim of this study was to investigate CIMT and serum PON1 activities along with lipid parameters in H. pylori positive and negative subjects. Methods Thirty H. pylori positive subjects and thirty-one negative subjects were enrolled. H. pylori infection was diagnosed by the presence of positivity of stool H. pylori antigen test or Carbon 14 labeled urea breath test. Serum PON1 activity was measured spectrophotometrically. Traditional cardiovascular risk factors were investigated and laboratory analysis included measurement of serum triglycerides (TG), total cholesterol (TC), high-density lipoprotein (HDL-C) and low-density lipoprotein cholesterol (LDL-C). We assessed CIMT by high-resolution ultrasound of both common carotid arteries. Results We found that the mean and maximum values of right and overall CIMT in H. pylori positive subjects were significantly thicker than those of H. pylori negative subjects. There was no significant differences in serum HDL-C, LDL-C, TC levels and TC/HDL-C ratios between two groups. Serum TG levels of H. pylori positive subjects were significantly higher than those of H. pylori negative subjects (p = 0.014). We found that PON1 activities were significantly lower in H. pylori positive subjects compared with negative subjects. No significantly correlation was observed between PON1 and CIMT values. Conclusions There is an increase in CIMT values in patients with H. pylori positive compared to H. pylori negative subjects. PON1 activity decrease significantly in H. pylori positive subjects. However, an association between PON1 and CIMT was not found. These data indicated that H. pylori may have a role in atherosclerotic processes, however, further studies are needed to evaluate the exact mechanisms.
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            Regulation of reverse cholesterol transport - a comprehensive appraisal of available animal studies

            Wijtske Annema, Uwe JF Tietge (2012)
            Plasma levels of high density lipoprotein (HDL) cholesterol are strongly inversely correlated to the risk of atherosclerotic cardiovascular disease. A major recognized functional property of HDL particles is to elicit cholesterol efflux and consequently mediate reverse cholesterol transport (RCT). The recent introduction of a surrogate method aiming at determining specifically RCT from the macrophage compartment has facilitated research on the different components and pathways relevant for RCT. The current review provides a comprehensive overview of studies carried out on macrophage-specific RCT including a quick reference guide of available data. Knowledge and insights gained on the regulation of the RCT pathway are summarized. A discussion of methodological issues as well as of the respective relevance of specific pathways for RCT is also included.
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              Paraoxonase 1 (PON1) 55 polymorphism, lipid profiles and psoriasis.

              T Pourmotabbed, H Tavilani, H. Nomani … (2012)
              Paraoxonase 1 (PON1) is a serum high-density lipoprotein-bound enzyme with antioxidant function. It hydrolyses lipid peroxides, protecting low-density lipoproteins from oxidative modifications. Patients with psoriasis are at greater risk of oxidative stress, which is associated with abnormal plasma lipid metabolism.
              Article 0 comments Cited 24 times – based on 0 reviews     Review now
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                Author and article information

                Contributors
                Yongyan Song: +86-817-3352032 , songyongyan2014@foxmail.com
                Journal
                Journal ID (nlm-ta): Lipids Health Dis
                Journal ID (iso-abbrev): Lipids Health Dis
                Title: Lipids in Health and Disease
                Publisher: BioMed Central (London )
                ISSN (Electronic): 1476-511X
                Publication date (Electronic): 3 December 2018
                Publication date PMC-release: 3 December 2018
                Publication date Collection: 2018
                Volume: 17
                Electronic Location Identifier: 274
                Affiliations
                [1 ]ISNI 0000 0004 1758 177X, GRID grid.413387.a, Department of Cardiology, , Affiliated Hospital of North Sichuan Medical College, ; Nanchong, 637000 People’s Republic of China
                [2 ]ISNI 0000 0004 1798 4472, GRID grid.449525.b, School of Continuing Education, North Sichuan Medical College, ; Nanchong, 637000 People’s Republic of China
                [3 ]ISNI 0000 0004 1799 2448, GRID grid.443573.2, Department of Neurology, , Taihe Hospital of Hubei University of Medicine, ; Shiyan, Hubei 442000 People’s Republic of China
                [4 ]ISNI 0000 0004 1798 4472, GRID grid.449525.b, Department of Medical Biochemistry, and Nanchong Key Laboratory of Metabolic Drugs and Biological Products, , North Sichuan Medical College, ; Nanchong, 637000 People’s Republic of China
                Article
                Publisher ID: 924
                DOI: 10.1186/s12944-018-0924-0
                PMC ID: 6278118
                PubMed ID: 30509298
                SO-VID: e6d9841d-04ec-481d-b046-b1611fbb532b
                Copyright © © The Author(s). 2018
                License:

                Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License ( http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

                History
                Date received : 5 September 2018
                Date accepted : 21 November 2018
                Funding
                Funded by: the Key Project of Education Department of Sichuan Province, China/the Cooperative Project on Scientific Research between Nanchong city and North Sichuan Medical College, P. R. China
                Award ID: 17ZA0172/NSMC20170403
                Categories
                Subject: Research
                Custom metadata
                issue-copyright-statement © The Author(s) 2018

                ScienceOpen disciplines: Biochemistry
                Keywords: paraoxonase 1,polymorphism,lipids,meta-analysis
                Data availability:
                ScienceOpen disciplines: Biochemistry
                Keywords: paraoxonase 1, polymorphism, lipids, meta-analysis

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