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Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis.

Nature reviews. Cancer

genetics, Transcription Factors, metabolism, Sterol Regulatory Element Binding Protein 1, Protein-Serine-Threonine Kinases, Phenotype, Nuclear Proteins, pathology, enzymology, drug therapy, Neoplasms, Neoplasm Metastasis, Neoplasm Invasiveness, Multienzyme Complexes, Lipogenesis, Humans, Glucose, Genes, BRCA1, biosynthesis, Fatty Acids, antagonists & inhibitors, Fatty Acid Synthases, Cell Death, Carcinoma in Situ, pharmacology, Antineoplastic Agents, AMP-Activated Protein Kinases

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      There is a renewed interest in the ultimate role of fatty acid synthase (FASN)--a key lipogenic enzyme catalysing the terminal steps in the de novo biogenesis of fatty acids--in cancer pathogenesis. Tumour-associated FASN, by conferring growth and survival advantages rather than functioning as an anabolic energy-storage pathway, appears to necessarily accompany the natural history of most human cancers. A recent identification of cross-talk between FASN and well-established cancer-controlling networks begins to delineate the oncogenic nature of FASN-driven lipogenesis. FASN, a nearly-universal druggable target in many human carcinomas and their precursor lesions, offers new therapeutic opportunities for metabolically treating and preventing cancer.

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