Embryonic hematopoiesis modulates the inflammatory response and larval hematopoiesis in  Drosophila

Author(s): Wael Bazzi ¹ ^, ² ^, ³ ^, ⁴ , Pierre B Cattenoz ¹ ^, ² ^, ³ ^, ⁴ , Claude Delaporte ¹ ^, ² ^, ³ ^, ⁴ , Vasanthi Dasari ¹ ^, ² ^, ³ ^, ⁴ , Rosy Sakr ¹ ^, ² ^, ³ ^, ⁴ , Yoshihiro Yuasa ¹ ^, ² ^, ³ ^, ⁴ , Angela Giangrande ¹ ^, ² ^, ³ ^, ⁴ ^,

Editor(s): Utpal Banerjee

Publication date (Electronic, pub): 11 July 2018

Journal: eLife

Publisher: eLife Sciences Publications, Ltd

Keywords: Drosophila, hematopoiesis, JAK/STAT, inflammation, transcription factors, Gcm, D. melanogaster

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Abstract

Recent lineage tracing analyses have significantly improved our understanding of immune system development and highlighted the importance of the different hematopoietic waves. The current challenge is to understand whether these waves interact and whether this affects the function of the immune system. Here we report a molecular pathway regulating the immune response and involving the communication between embryonic and larval hematopoietic waves in Drosophila. Down-regulating the transcription factor Gcm specific to embryonic hematopoiesis enhances the larval phenotypes induced by over-expressing the pro-inflammatory Jak/Stat pathway or by wasp infestation. Gcm works by modulating the transduction of the Upd cytokines to the site of larval hematopoiesis and hence the response to chronic (Jak/Stat over-expression) and acute (wasp infestation) immune challenges. Thus, homeostatic interactions control the function of the immune system in physiology and pathology. Our data also indicate that a transiently expressed developmental pathway has a long-lasting effect on the immune response.

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Author and article information

Contributors

Angela Giangrande:

ORCID: http://orcid.org/0000-0001-6278-5120

Utpal Banerjee: Role: Reviewing Editor

Journal

Journal ID (nlm-ta): eLife

Journal ID (iso-abbrev): Elife

Journal ID (publisher-id): eLife

Title: eLife

Publisher: eLife Sciences Publications, Ltd

ISSN (Electronic): 2050-084X

Publication date (Electronic, pub): 11 July 2018

Publication date Collection: 2018

Volume: 7

Electronic Location Identifier: e34890

Affiliations

[1 ]Institut de Génétique et de Biologie Moléculaire et Cellulaire IllkirchFrance

[2 ]deptUMR7104 Centre National de la Recherche Scientifique IllkirchFrance

[3 ]deptU1258 Institut National de la Santé et de la Recherche Médicale IllkirchFrance

[4 ]Université de Strasbourg IllkirchFrance

[5]University of California, Los Angeles United States

[6]University of California, Los Angeles United States

Author notes

^†These authors contributed equally to this work.

[†]

These authors contributed equally to this work.

Author information

Pierre B Cattenoz https://orcid.org/0000-0001-5301-1975

Angela Giangrande http://orcid.org/0000-0001-6278-5120

Article

Publisher ID: 34890

DOI: 10.7554/eLife.34890

PMC ID: 6040882

PubMed ID: 29992900

SO-VID: e71557d4-f11f-4d2f-9c63-4450ba6825e4

License:

This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.

History

Date received : 08 January 2018

Date accepted : 18 June 2018

Funding

Funded by: FundRef http://dx.doi.org/10.13039/501100001677, Institut National de la Santé et de la Recherche Médicale;