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      Application of chitosan-based polysaccharide biomaterials in cartilage tissue engineering: a review

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      Biomaterials
      Elsevier BV

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          Abstract

          Once damaged, articular cartilage has very little capacity for spontaneous healing because of the avascular nature of the tissue. Although many repair techniques have been proposed over the past four decades, none has sucessfully regenerated long-lasting hyaline cartilage tissue to replace damaged cartilage. Tissue engineering approaches, such as transplantation of isolated chondrocytes, have recently demonstrated tremendous clinical potential for regeneration of hyaline-like cartilage tissue and treatment of chondral lesions. As such a new approach emerges, new important questions arise. One of such questions is: what kinds of biomaterials can be used with chondrocytes to tissue-engineer articular cartilage? The success of chondrocyte transplantation and/or the quality of neocartilage formation strongly depend on the specific cell-carrier material. The present article reviews some of those biomaterials, which have been suggested to promote chondrogenesis and to have potentials for tissue engineering of articular cartilage. A new biomaterial, a chitosan-based polysaccharide hydrogel, is also introduced and discussed in terms of the biocompatibility with chondrocytes.

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          Author and article information

          Journal
          Biomaterials
          Biomaterials
          Elsevier BV
          01429612
          December 2000
          December 2000
          : 21
          : 24
          : 2589-2598
          Article
          10.1016/S0142-9612(00)00126-5
          11071608
          e7bbcffa-e038-40d4-99c9-e57ff3f1de00
          © 2000

          https://www.elsevier.com/tdm/userlicense/1.0/

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