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      Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

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      Nature Protocols
      Springer Science and Business Media LLC

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          Abstract

          DAVID bioinformatics resources consists of an integrated biological knowledgebase and analytic tools aimed at systematically extracting biological meaning from large gene/protein lists. This protocol explains how to use DAVID, a high-throughput and integrated data-mining environment, to analyze gene lists derived from high-throughput genomic experiments. The procedure first requires uploading a gene list containing any number of common gene identifiers followed by analysis using one or more text and pathway-mining tools such as gene functional classification, functional annotation chart or clustering and functional annotation table. By following this protocol, investigators are able to gain an in-depth understanding of the biological themes in lists of genes that are enriched in genome-scale studies.

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          Author and article information

          Journal
          Nature Protocols
          Nat Protoc
          Springer Science and Business Media LLC
          1754-2189
          1750-2799
          January 2009
          December 18 2008
          January 2009
          : 4
          : 1
          : 44-57
          Article
          10.1038/nprot.2008.211
          19131956
          e8fdc775-0944-4a45-b823-526ffbb7ecdc
          © 2009

          http://www.springer.com/tdm

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