Circuit Topology Analysis of Polymer Folding Reactions

Abstract

Circuit topology is emerging as a versatile measure to classify the internal structures of folded linear polymers such as proteins and nucleic acids. The topology framework can be applied to a wide range of problems, most notably molecular folding reactions that are central to biology and molecular engineering. In this Outlook, we discuss the state-of-the art of the technology and elaborate on the opportunities and challenges that lie ahead.

Abstract

Circuit topology categorizes intrachain contacts of a folded linear molecular chain. Contacts can be in series, in parallel, or in cross arrangements. Circuit topology of a folded linear molecular chain determines its folding and unfolding dynamics. Folding of a molecular chain can be guided to desired topologies by introducing transient internal or external confinement.