1,189
views
0
recommends
+1 Recommend
1 collections
    0
    shares
      • Record: found
      • Abstract: not found
      • Article: not found

      Astrocyte–endothelial interactions at the blood–brain barrier

      , ,
      Nature Reviews Neuroscience
      Springer Science and Business Media LLC

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          The blood-brain barrier, which is formed by the endothelial cells that line cerebral microvessels, has an important role in maintaining a precisely regulated microenvironment for reliable neuronal signalling. At present, there is great interest in the association of brain microvessels, astrocytes and neurons to form functional 'neurovascular units', and recent studies have highlighted the importance of brain endothelial cells in this modular organization. Here, we explore specific interactions between the brain endothelium, astrocytes and neurons that may regulate blood-brain barrier function. An understanding of how these interactions are disturbed in pathological conditions could lead to the development of new protective and restorative therapies.

          Related collections

          Author and article information

          Journal
          Nature Reviews Neuroscience
          Nat Rev Neurosci
          Springer Science and Business Media LLC
          1471-003X
          1471-0048
          January 2006
          January 2006
          : 7
          : 1
          : 41-53
          Article
          10.1038/nrn1824
          16371949
          eb442bca-da9b-4a51-8c01-e6f9d929152d
          © 2006

          http://www.springer.com/tdm

          History

          Comments

          Comment on this article