[1
] Center for Human Genetic Research, Massachusetts General Hospital, 185 Cambridge
Street, Boston, MA 02114, USA
[2
] Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts
02114, USA
[3
] Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts
Institute of Technology, Cambridge, Massachusetts, 02142, USA
[4
] Department of Medical Genetics, University of Lausanne, 1005 Lausanne, Switzerland
[5
] University Institute for Social and Preventative Medicine, Centre Hospitalier Universitaire
Vaudois (CHUV) and University of Lausanne, 1005 Lausanne, Switzerland
[6
] Swiss Institute of Bioinformatics, Switzerland
[7
] Department of Biostatistics and Center for Statistical Genetics, University of Michigan,
Ann Arbor, MI 48109, USA
[8
] Departments of Health Sciences & Genetics, Adrian Building, University of Leicester,
University Road, Leicester LE1 7RH
[9
] Department of Epidemiology and Public Health, Imperial College London, St Mary’s
Campus, Norfolk Place, London W2 1PG, UK
[10
] Laboratory of Cardiovascular Science, Intramural Research Program, National Institute
on Aging, National Institutes of Health, Baltimore, Maryland, USA 21224
[11
] MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge
CB2 0QQ, UK
[12
] Cambridge - Genetics of Energy Metabolism (GEM) Consortium, Cambridge, UK
[13
] Centre National de Génotypage, 2 rue Gaston Crémieux, CP 5721, 91 057 Evry Cedex,
France
[14
] Pontificia Universidad Catolica de Chile, Vicuna Mackenna 4860, Facultad de Matematicas,
Casilla 306, Santiago 22, Chile, 7820436
[15
] Institute of Epidemiology, Helmholtz Zentrum München, German Research Centre for
Environmental Health, 85764 Neuherberg, Germany
[16
] Division of Community Health Sciences, St George’s, University of London, London
SW17 0RE, UK
[17
] Dept of Twin Research & Genetic Epidemiology, King’s College London, London SE1 7EH
[18
] Dept. Cardiovascular Medicine, University of Oxford
[19
] The Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford, OX3 7BN, UK
[20
] Medstar Research Institute, 3001 S. Hanover Street, Baltimore, MD 21250, USA
[21
] Clinical Research Branch, National Institute on Aging, Baltimore, MD, 21250 USA
[22
] Clinical Pharmacology and The Genome Centre, William Harvey Research Institute, Barts
and The London School of Medicine and Dentistry, Queen Mary University of London,
London EC1M 6BQ
[23
] JDRF/WT Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research
University of Cambridge, Wellcome Trust/MRC Building, Addenbrooke’s Hospital Cambridge,
CB2 0XY
[24
] Department of Public Health and Primary Care, Institute of Public Health, University
of Cambridge, Cambridge CB2 2SR, UK
[25
] Department of Clinical Sciences, Lund University, Malmö University Hospital, SE-20502
Malmö, Sweden
[26
] Department of Cardiology University Medical Center Groningen, University of Groningen,
Hanzeplein 1, 9700 RB Groningen, The Netherlands
[27
] ISI Foundation (Institute for Scientific Interchange), Villa Gualino, Torino, 10133,
Italy
[28
] Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht,
STR 6.131, PO Box 85500, 3508 GA Utrecht, The Netherlands
[29
] Complex Genetics Section, Department of Medical Genetics - DBG, University Medical
Center Utrecht, STR 2.2112, PO Box 85500, 3508 GA Utrecht, The Netherlands
[30
] Interfaculty Institute for Genetics and Functional Genomics, Ernst-Moritz-Arndt-University
Greifswald, 17487 Greifswald, Germany
[31
] Cardiovascular Epidemiology and Genetics, Institut Municipal d’Investigació Mèdica,
Barcelona, Spain
[32
] Department of Medicine University of Kuopio 70210 Kuopio, Finland
[33
] ALSPAC Laboratory, Department of Social Medicine, University of Bristol, BS8 2BN,
UK
[34
] A full list of authors is provided in the
supplementary methods online
[35
] Clinical Pharmacology Unit, University of Cambridge, Addenbrookes Hospital, Cambridge,
UK CB2 2QQ
[36
] BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK G12
8TA
[37
] Dept of Cardiovascular Science, University of Leicester, Glenfield Hospital, Groby
Road, Leicester, LE3 9QP, UK
[38
] Aberdeen Royal Infirmary, Aberdeen, UK
[39
] Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge
CB10 1SA, UK
[40
] Service of Medical Genetics, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne,
1011, Switzerland
[41
] Genetics Division, GlaxoSmithKline, King of Prussia, PA 19406, USA
[42
] Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois (CHUV)
1011 Lausanne, Switzerland
[43
] Department of Clinical Sciences, Diabetes and Endocrinology Research Unit, University
Hospital, Malmö
[44
] Lund University, Malmö S-205 02, Sweden
[45
] Department of Genetics, Biology and Biochemistry, University of Torino, Torino, 10126,
Italy
[46
] Department of Clinical and Experimental Medicine, Federico II University, Naples,
80100, Italy
[47
] Unit of Cancer Epidemiology, University of Turin and Centre for Cancer Epidemiology
and Prevention (CPO Piemonte), Turin, 10126, Italy
[48
] National Institute for Welfare and Health P.O. Box 30, FI-00271 Helsinki, Finland
[49
] Institute for Molecular Medicine Finland FIMM, University of Helsinki and National
Public Health Institute
[50
] Genome Technology Branch, National Human Genome Research Institute, Bethesda, MD
20892, USA
[51
] Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA
[52
] Diabetes Unit, Department of Epidemiology and Health Promotion, National Public Health
Institute, 00300 Helsinki, Finland
[53
] Physiology and Biophysics USC School of Medicine 1333 San Pablo Street, MMR 626 Los
Angeles, California 90033
[54
] Institute of Human Genetics, Helmholtz Zentrum Munchen, German Research Centre for
Environmental Health, 85764 Neuherberg, Germany
[55
] Institute of Human Genetics, Technische Universität München, 81675 Munich, Germany
[56
] Institute of Molecular and Cell Biology, University of Tartu, 51010 Tartu, Estonia
[57
] Ludwig Maximilians University, IBE, Chair of Epidemiology, Munich
[58
] Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital,
Boston, Massachusetts 02114, USA
[59
] Framingham Heart Study and National, Heart, Lung, and Blood Institute, Framingham,
Massachusetts 01702, USA
[60
] Cardiovascular Health Research Unit, Departments of Medicine and Epidemiology, University
of Washington, Seattle, Washington, 98101 USA
[61
] Department of Epidemiology, University of Washington, Seattle, Washington, 98195
USA
[62
] CIBER Epidemiología y Salud Pública, Barcelona, Spain
[63
] Center for Neurobehavioral Genetics, Gonda Center, Room 3506, 695 Charles E Young
Drive South, Box 951761, UCLA, Los Angeles, CA 90095
[64
] Department of Clinical Sciences/Obstetrics and Gynecology, P.O. Box 5000 Fin-90014,
University of Oulu, Finland
[65
] Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill
Hospital, Old Road, Headington, Oxford OX3 7LJ, UK
[66
] Oxford NIHR Biomedical Research Centre, Churchill Hospital, Old Road, Headington,
Oxford, UK OX3 7LJ
[67
] Department of Child and Adolescent Health, National Public Health Institute (KTL),
Aapistie 1, P.O. Box 310, FIN-90101 Oulu, Finland
[68
] Division of Nephrology, Department of Medicine University Medical Center Groningen,
University of Groningen, Hanzeplein 1, 9700 RB Groningen, The Netherlands
[69
] Unit of Genetic Epidemiology and Bioinformatics, Department of Epidemiology University
Medical Center Groningen, University of Groningen, Hanzeplein 1, 9700 RB Groningen,
The Netherlands
[70
] Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), University of
Oxford, Richard Doll Building, Roosevelt Drive, Oxford, OX3 7LF, UK
[71
] Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet,
Karolinska University Hospital Solna, Building L8:03, S-17176 Stockholm, Sweden
[72
] Leibniz-Institut für Arterioskleroseforschung an der Universität Münster, Domagkstr.
3, D-48149, Münster, Germany
[73
] Molecular Medicine, Dept. Medical Sciences, Uppsala University, SE-751 85 Uppsala,
Sweden
[74
] Consorzio Mario Negri Sud, Via Nazionale, 66030 Santa Maria Imbaro (Chieti), Italy
[75
] Istituto di Neurogenetica e Neurofarmacologia, CNR, Monserrato, 09042 Cagliari, Italy
[76
] Department of Epidemiology, Univ. of Texas M. D. Anderson Cancer Center, Houston,
TX 77030
[77
] Laboratory of Genetics, Intramural Research Program, National Institute on Aging,
National Institutes of Health, Baltimore, Maryland, USA 21224
[78
] Unitá Operativa Geriatria, Istituto Nazionale Ricovero e Cura per Anziani (INRCA)
IRCCS, Rome, Italy
[79
] Department of Internal Medicine B, Ernst-Moritz-Arndt-University Greifswald, 17487
Greifswald, Germany
[80
] Institute for Community Medicine, Ernst-Moritz-Arndt-University Greifswald, 17487
Greifswald, Germany
[81
] Institute of Physiology, Ernst-Moritz-Arndt-University Greifswald, 17487 Greifswald,
Germany
[82
] U557 Institut National de la Sante et de la Recherche Médicale, U1125 Institut National
de la Recherche Agronomique, Université Paris 13, 74 rue Marcel Cachin, 93017 Bobigny
Cedex, France
[83
] MRC Dunn Human Nutrition Unit, Wellcome Trust/MRC Building, Cambridge CB2 0XY, U.K
[84
] National Heart and Lung Institute, Imperial College London SW7 2AZ
[85
] Program in Genetics and Genome Biology, Hospital for Sick Children, Toronto, Canada,
Dalla Lana School of Public Health, University of Toronto, Toronto, Canada M5T 3M7
[86
] Geriatric Rehabilitation Unit, Azienda Sanitaria Firenze (ASF), 50125, Florence,
Italy
[87
] Department of Public Health, University of Helsinki, 00014 Helsinki, Finland
[88
] South Ostrobothnia Central Hospital, 60220 Seinäjoki, Finland
[89
] Department of Medicine and Department of Genetics, Harvard Medical School, Boston,
Massachusetts 02115, USA
[90
] Diabetes Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
[91
] U872 Institut National de la Santét de la Recherche Médicale, Faculté de Médecine
Paris Descartes, 15 rue de l’Ecole de Medé0cine, 75270 Paris Cedex, France
[92
] Institute of Health Sciences and Biocenter Oulu, Aapistie 1, FIN-90101, University
of Oulu, Finland
[93
] Center for Statistical Genetics, Department of Biostatistics, University of Michigan,
Ann Arbor, Michigan 48109 USA
