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      Coarse-grained models and collective phenomena in membranes: Computer simulation of membrane fusion : Highlight

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      Journal of Polymer Science Part B: Polymer Physics

      Wiley

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          Most cited references 53

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          Polymer vesicles.

          Vesicles are microscopic sacs that enclose a volume with a molecularly thin membrane. The membranes are generally self-directed assemblies of amphiphilic molecules with a dual hydrophilic-hydrophobic character. Biological amphiphiles form vesicles central to cell function and are principally lipids of molecular weight less than 1 kilodalton. Block copolymers that mimic lipid amphiphilicity can also self-assemble into vesicles in dilute solution, but polymer molecular weights can be orders of magnitude greater than those of lipids. Structural features of vesicles, as well as properties including stability, fluidity, and intermembrane dynamics, are greatly influenced by characteristics of the polymers. Future applications of polymer vesicles will rely on exploiting unique property-performance relations, but results to date already underscore the fact that biologically derived vesicles are but a small subset of what is physically and chemically possible.
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            Polymersomes: tough vesicles made from diblock copolymers.

            Vesicles were made from amphiphilic diblock copolymers and characterized by micromanipulation. The average molecular weight of the specific polymer studied, polyethyleneoxide-polyethylethylene (EO40-EE37), is several times greater than that of typical phospholipids in natural membranes. Both the membrane bending and area expansion moduli of electroformed polymersomes (polymer-based liposomes) fell within the range of lipid membrane measurements, but the giant polymersomes proved to be almost an order of magnitude tougher and sustained far greater areal strain before rupture. The polymersome membrane was also at least 10 times less permeable to water than common phospholipid bilayers. The results suggest a new class of synthetic thin-shelled capsules based on block copolymer chemistry.
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              Configurations of fluid membranes and vesicles

               Udo Seifert (1997)
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                Author and article information

                Journal
                Journal of Polymer Science Part B: Polymer Physics
                J. Polym. Sci. B Polym. Phys.
                Wiley
                08876266
                July 01 2003
                July 01 2003
                May 16 2003
                : 41
                : 13
                : 1441-1450
                Article
                10.1002/polb.10456
                ef360e5f-3b5d-46f4-8e1e-67a018e65e09
                © 2003
                Product
                Self URI (article page): http://doi.wiley.com/10.1002/polb.10456

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