Harnessing regulatory T cells to establish immune tolerance

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Abstract

Engineered regulatory T (T _reg ) cells have emerged as precision therapeutics aimed at inducing immune tolerance while reducing the risks associated with generalized immunosuppression. This Viewpoint highlights the opportunities and challenges for engineered T _reg cell therapies in treating autoimmune and other inflammatory diseases.

Abstract

T _reg therapies for autoimmune and inflammatory diseases offer both opportunities and challenges.

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Patrick Ho: (View ORCID Profile)

Ellen Cahir-McFarland: (View ORCID Profile)

Jason D. Fontenot: (View ORCID Profile)

Tracey Lodie: (View ORCID Profile)

Qizhi Tang: (View ORCID Profile)

Jeffrey A. Bluestone: (View ORCID Profile)

Journal

Title: Science Translational Medicine

Abbreviated Title: Sci. Transl. Med.

Publisher: American Association for the Advancement of Science (AAAS)

ISSN (Print): 1946-6234

ISSN (Electronic): 1946-6242

Publication date Created: March 13 2024

Publication date (Print): March 13 2024

Volume: 16

Issue: 738

Affiliations

[1 ]Diabetes Center, University of California San Francisco, San Francisco, CA 94143, USA.

[2 ]Abata Therapeutics, Boston, MA 02472, USA.

[3 ]Sangamo Therapeutics, Brisbane, CA 94005, USA.

[4 ]Quell Therapeutics, London W12 OBZ, UK.

[5 ]GentiBio, Cambridge, MA 02140, USA.

[6 ]Department of Surgery, University of California San Francisco, San Francisco, CA 94143, USA.

[7 ]Gladstone Institute of Genomic Immunology, University of California San Francisco, San Francisco, CA 94143, USA.

[8 ]Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco, CA 94143, USA.

[9 ]Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA.

[10 ]Sonoma Biotherapeutics, South San Francisco, CA 09080, USA.

Article

DOI: 10.1126/scitranslmed.adm8859

PubMed ID: 38478632

SO-VID: f243c880-56d6-4b7c-ba16-09fce24ccc20

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Harnessing regulatory T cells to establish immune tolerance

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Abstract

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