Research progress of exosomes in the angiogenesis of digestive system tumour

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Abstract

Malignant tumours of the digestive system cover a wide range of diseases that affect the health of people to a large extent. Angiogenesis is indispensable in the development, and metastasis of tumours, mainly in two ways: occupation or formation. Vessels can provide nutrients, oxygen, and growth factors for tumours to encourage growth and metastasis, so cancer progression depends on simultaneous angiogenesis. Recently, exosomes have been proven to participate in the angiogenesis of tumours. They influence angiogenesis by binding to tyrosine kinase receptors (VEGFR)-1, VEGFR-2, and VEGFR-3 with different affinities, regulating Yap-VEGF pathway, Akt pathway or other signaling pathway. Additionally, exosomes are potential therapeutic vectors that can deliver many types of cargoes to different cells. In this review, we summarize the roles of exosomes in the angiogenesis of digestive system tumours and highlight the clinical application prospects, directly used as targers or delivery vehicles, in antiangiogenic therapy.

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Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung, Jacques Ferlay, Rebecca Siegel … (2021)

This article provides an update on the global cancer burden using the GLOBOCAN 2020 estimates of cancer incidence and mortality produced by the International Agency for Research on Cancer. Worldwide, an estimated 19.3 million new cancer cases (18.1 million excluding nonmelanoma skin cancer) and almost 10.0 million cancer deaths (9.9 million excluding nonmelanoma skin cancer) occurred in 2020. Female breast cancer has surpassed lung cancer as the most commonly diagnosed cancer, with an estimated 2.3 million new cases (11.7%), followed by lung (11.4%), colorectal (10.0 %), prostate (7.3%), and stomach (5.6%) cancers. Lung cancer remained the leading cause of cancer death, with an estimated 1.8 million deaths (18%), followed by colorectal (9.4%), liver (8.3%), stomach (7.7%), and female breast (6.9%) cancers. Overall incidence was from 2-fold to 3-fold higher in transitioned versus transitioning countries for both sexes, whereas mortality varied <2-fold for men and little for women. Death rates for female breast and cervical cancers, however, were considerably higher in transitioning versus transitioned countries (15.0 vs 12.8 per 100,000 and 12.4 vs 5.2 per 100,000, respectively). The global cancer burden is expected to be 28.4 million cases in 2040, a 47% rise from 2020, with a larger increase in transitioning (64% to 95%) versus transitioned (32% to 56%) countries due to demographic changes, although this may be further exacerbated by increasing risk factors associated with globalization and a growing economy. Efforts to build a sustainable infrastructure for the dissemination of cancer prevention measures and provision of cancer care in transitioning countries is critical for global cancer control.

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Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines

Clotilde Théry, Kenneth W Witwer, Elena Aikawa … (2019)

ABSTRACT The last decade has seen a sharp increase in the number of scientific publications describing physiological and pathological functions of extracellular vesicles (EVs), a collective term covering various subtypes of cell-released, membranous structures, called exosomes, microvesicles, microparticles, ectosomes, oncosomes, apoptotic bodies, and many other names. However, specific issues arise when working with these entities, whose size and amount often make them difficult to obtain as relatively pure preparations, and to characterize properly. The International Society for Extracellular Vesicles (ISEV) proposed Minimal Information for Studies of Extracellular Vesicles (“MISEV”) guidelines for the field in 2014. We now update these “MISEV2014” guidelines based on evolution of the collective knowledge in the last four years. An important point to consider is that ascribing a specific function to EVs in general, or to subtypes of EVs, requires reporting of specific information beyond mere description of function in a crude, potentially contaminated, and heterogeneous preparation. For example, claims that exosomes are endowed with exquisite and specific activities remain difficult to support experimentally, given our still limited knowledge of their specific molecular machineries of biogenesis and release, as compared with other biophysically similar EVs. The MISEV2018 guidelines include tables and outlines of suggested protocols and steps to follow to document specific EV-associated functional activities. Finally, a checklist is provided with summaries of key points.

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The biology, function, and biomedical applications of exosomes

Raghu Kalluri, Valerie LeBleu (2020)

The study of extracellular vesicles (EVs) has the potential to identify unknown cellular and molecular mechanisms in intercellular communication and in organ homeostasis and disease. Exosomes, with an average diameter of ~100 nanometers, are a subset of EVs. The biogenesis of exosomes involves their origin in endosomes, and subsequent interactions with other intracellular vesicles and organelles generate the final content of the exosomes. Their diverse constituents include nucleic acids, proteins, lipids, amino acids, and metabolites, which can reflect their cell of origin. In various diseases, exosomes offer a window into altered cellular or tissue states, and their detection in biological fluids potentially offers a multicomponent diagnostic readout. The efficient exchange of cellular components through exosomes can inform their applied use in designing exosome-based therapeutics.

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Author and article information

Contributors

Wei Chong:

ORCID: http://orcid.org/0000-0002-1074-8595

chongwei@sdfmu.edu.cn , chongwei.good@163.com

Liang Shang:

ORCID: http://orcid.org/0000-0002-9542-7650

docshang@163.com

Leping Li:

ORCID: http://orcid.org/0000-0003-2329-6791

lileping@medmail.com.cn , lileping@mail.sdu.edu.cn

Journal

Journal ID (nlm-ta): Discov Oncol

Journal ID (iso-abbrev): Discov Oncol

Title: Discover. Oncology

Publisher: Springer US (New York )

ISSN (Electronic): 2730-6011

Publication date (Electronic): 11 February 2024

Publication date PMC-release: 11 February 2024

Publication date Collection: December 2024

Volume: 15

Electronic Location Identifier: 33

Affiliations

[1 ]GRID grid.460018.b, ISNI 0000 0004 1769 9639, Department of Gastroenterological Surgery, , Shandong Provincial Hospital, Shandong University, ; Jinan, 250021 Shandong China

[2 ]GRID grid.413106.1, ISNI 0000 0000 9889 6335, Department of General Surgery, , Peking Union Medical College, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, ; Beijing, 100730 China

[3 ]GRID grid.460018.b, ISNI 0000 0004 1769 9639, Department of Gastrointestinal Surgery, Key Laboratory of Engineering of Shandong Province, , Shandong Provincial Hospital Affiliated to Shandong First Medical University, Shandong Provincial Hospital, ; Jinan, 250021 China

[4 ]GRID grid.27255.37, ISNI 0000 0004 1761 1174, Department of Gastrointestinal Surgery, Medical Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, , Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, ; Jinan, 250021 China

Author information

Yuan Liu http://orcid.org/0009-0003-1845-6495

Hao Wu http://orcid.org/0000-0001-9222-2521

Yaodong Sang http://orcid.org/0009-0003-3277-7201

Wei Chong http://orcid.org/0000-0002-1074-8595

Liang Shang http://orcid.org/0000-0002-9542-7650

Leping Li http://orcid.org/0000-0003-2329-6791

Article

Publisher ID: 879

DOI: 10.1007/s12672-024-00879-4

PMC ID: 10859358

PubMed ID: 38341827

SO-VID: f2f7e0d2-507a-4ad9-a239-650a61fcfe3b

License:

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

History

Date received : 7 July 2023

Date accepted : 30 January 2024

Funding

Funded by: National Natural Scientific Foundation of China

Award ID: 82102702

Award Recipient : Wei Chong

Funded by: The Research Incubation Funding of Shandong Provincial Hospital

Award ID: 2020FY035

Award Recipient : Wei Chong

Funded by: Natural Science Foundation of Shandong Province of China

Award ID: ZR2021QH141

Award Recipient : Wei Chong

Funded by: China Postdoctoral Science Foundation

Award ID: 2022M711970

Award Recipient : Wei Chong

Funded by: Clinical Medical Science and Technology Innovation Project of Jinan

Award ID: 202225046

Award Recipient : Wei Chong

Funded by: Youth Innovation Science and Technology Program of Shandong Provincial Universities

Award ID: 2022KJ187

Award Recipient : Wei Chong

Funded by: National Natural Science Foundation of China

Award ID: 82203854

Award Recipient : Liang Shang

Funded by: Key Research and Development Program of Shandong Province

Award ID: No.2021CXGC011104

Award Recipient : Leping Li

Funded by: Academic promotion programme of Shandong First Medical University

Award ID: 2019QL021

Award Recipient : Leping Li

Funded by: Special Foundation for Taishan Scholars Program of Shandong Province

Award ID: No.ts20190978

Award Recipient : Leping Li

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Keywords: exosome,angiogenesis,antiangiogenic therapy,digestive system tumour

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Keywords: exosome, angiogenesis, antiangiogenic therapy, digestive system tumour

Research progress of exosomes in the angiogenesis of digestive system tumour

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Abstract

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Sex and gender-sensitive medicine

Most cited references 186

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines

The biology, function, and biomedical applications of exosomes

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Affiliations

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