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      188Re-SSS/Lipiodol: Development of a Potential Treatment for HCC from Bench to Bedside

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          Abstract

          Hepatocellular carcinoma (HCC) is the 5th most common tumour worldwide and has a dark prognosis. For nonoperable cases, metabolic radiotherapy with Lipiodol labelled with β-emitters is a promising therapeutic option. The Comprehensive Cancer Centre Eugène Marquis and the National Graduate School of Chemistry of Rennes (ENSCR) have jointly developed a stable and efficient labelling of Lipiodol with rhenium-188 (E βmax = 2.1 MeV) for the treatment of HCC. The major “milestones” of this development, from the first syntheses to the recent first injection in man, are described.

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          Global cancer statistics

          A. JEMAL, F Bray, MM Center … (2012)
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            Loco-regional treatment of hepatocellular carcinoma.

            Riccardo Lencioni (2010)
            Loco-regional treatments play a key role in the management of hepatocellular carcinoma (HCC). Image-guided tumor ablation is recommended in patients with early-stage HCC when surgical options are precluded. Radiofrequency ablation has shown superior anticancer effects and greater survival benefit with respect to the seminal percutaneous technique, ethanol injection, in meta-analyses of randomized controlled trials, and is currently established as the standard method for local tumor treatment. Novel thermal and nonthermal techniques for tumor ablation--including microwave ablation, irreversible electroporation, and light-activated drug therapy--seem to have potential to overcome the limitations of radiofrequency ablation and warrant further clinical investigation. Transcatheter arterial chemoembolization (TACE) is the standard of care for patients with asymptomatic, noninvasive multinodular tumors at the intermediate stage. The recent introduction of embolic microspheres that have the ability to release the drug in a controlled and sustained fashion has been shown to significantly increase safety and efficacy of TACE with respect to conventional, lipiodol-based regimens. The available data for radioembolization with yttrium-90 suggests that this is a potential new option for patients with HCC, which should be investigated in the setting of randomized controlled trials. Despite the advances and refinements in loco-regional approaches, the long-term survival outcomes of patients managed with interventional techniques are not fully satisfactory, mainly because of the high rates of tumor recurrence. The recent addition of molecular targeted drugs with antiangiogenic and antiproliferative properties to the therapeutic armamentarium for HCC has prompted the design of clinical trials aimed at investigating the synergies between loco-regional and systemic treatments. The outcomes of these trials are eagerly awaited, because they have the potential to revolutionize the treatment of HCC.
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              Hepatocellular carcinoma: the need for progress.

              Andy Z. X. Zhu, Stephen Thomas (2005)
              Article 0 comments Cited 89 times – based on 0 reviews     Review now
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                Author and article information

                Journal
                Journal ID (nlm-ta): Int J Mol Imaging
                Journal ID (iso-abbrev): Int J Mol Imaging
                Journal ID (publisher-id): IJMI
                Title: International Journal of Molecular Imaging
                Publisher: Hindawi Publishing Corporation
                ISSN (Print): 2090-1712
                ISSN (Electronic): 2090-1720
                Publication date (Print): 2012
                Publication date (Electronic): 22 February 2012
                Volume: 2012
                Electronic Location Identifier: 278306
                Affiliations
                1Centre Régional de Lutte Contre le Cancer Eugène Marquis, INSERM UMR-S 991, Avenue de la Bataille Flandres-Dunkerque, CS 44229, 35042 Rennes, France
                2Ecole Nationale Supérieure de Chimie de Rennes, CNRS UMR 6226, Avenue du Général Leclerc, CS 50837, 35708 Rennes, France
                3Université Européenne de Bretagne, 35000 Rennes, France
                Author notes

                Academic Editor: John Humm

                Article
                DOI: 10.1155/2012/278306
                PMC ID: 3299367
                PubMed ID: 22518301
                SO-VID: f5cd9877-d9ef-4ad2-aca5-fec2dab5a860
                Copyright © Copyright © 2012 Nicolas Lepareur et al.
                License:

                This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                Date received : 12 October 2011
                Date revision received : 8 December 2011
                Date accepted : 13 December 2011
                Categories
                Subject: Research Article

                ScienceOpen disciplines: Molecular biology
                Data availability:
                ScienceOpen disciplines: Molecular biology

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