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Anti-platelet aggregation constituents from formosan Toddalia asiatica
August 1998
August 1998
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Abstract
Examination on the wood of Formosan Toddalia asiatica led to the isolation of 30 compounds,
including coumarins, alkaloids, a benzoquinone and an amine. Among the isolates, (+/-)-toddanin
and (-)-isocoreximine are new compounds, while cyclohexylamine was isolated for the
first time from nature. The structures of the compounds were elucidated from spectroscopic
data and chemical evidence. Bioassay-guided fractionation led to the isolation of
seven compounds showing strong anti-platelet aggregation activity in vitro.