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Abstract
The main aim of this study was to evaluate putative associations between the interleukin
(IL)-6 c.-174G>C polymorphism (rs 1800795) and the cardiovascular outcome (combined
endpoint: myocardial infarction, stroke/TIA, cardiac death, death according to stroke)
among patients with coronary heart disease (CHD) within three years follow-up. Overall
942 in-patients with CHD were included. The drop-out rate was 4.9%. The IL-6 polymorphism
was determined with PCR-SSP. Kaplan-Meier plots with Log Rank test and Cox regression
were used as statistically procedures. The IL-6 CC genotype was associated with a
higher incidence of the combined endpoint (25.0% versus 13.5%, p<0.001) and an increased
Hazard Ratio (HR 2.165, 95% CI 1.516-3.092, p<0.001) adjusted for established cofactors
for CHD. This result suggests that the IL-6 -174 polymorphism is a putative independent
risk indicator for new cardiovascular events among patients with CHD.